226655

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1160300..1160920 Replicon chromosome
Accession NZ_CP088119
Organism Enterobacter kobei strain 6

Toxin (Protein)


Gene name Hha Uniprot ID A0A2W0G488
Locus tag LRM31_RS05505 Protein ID WP_014882802.1
Coordinates 1160300..1160518 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag LRM31_RS05510 Protein ID WP_008499288.1
Coordinates 1160546..1160920 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM31_RS05475 (LRM31_05475) 1156309..1156569 + 261 WP_047027759.1 type B 50S ribosomal protein L31 -
LRM31_RS05480 (LRM31_05480) 1156572..1156712 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LRM31_RS05485 (LRM31_05485) 1156709..1157419 - 711 WP_047027732.1 GNAT family protein -
LRM31_RS05490 (LRM31_05490) 1157521..1158981 + 1461 WP_047027733.1 PLP-dependent aminotransferase family protein -
LRM31_RS05495 (LRM31_05495) 1158953..1159420 - 468 WP_014882800.1 YlaC family protein -
LRM31_RS05500 (LRM31_05500) 1159539..1160090 - 552 WP_014882801.1 maltose O-acetyltransferase -
LRM31_RS05505 (LRM31_05505) 1160300..1160518 - 219 WP_014882802.1 HHA domain-containing protein Toxin
LRM31_RS05510 (LRM31_05510) 1160546..1160920 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
LRM31_RS05515 (LRM31_05515) 1161432..1164578 - 3147 WP_014882803.1 multidrug efflux RND transporter permease subunit AcrB -
LRM31_RS05520 (LRM31_05520) 1164601..1165794 - 1194 WP_014882804.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T226655 WP_014882802.1 NZ_CP088119:c1160518-1160300 [Enterobacter kobei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T226655 NZ_CP122588:4160829-4161107 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGCTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT226655 WP_008499288.1 NZ_CP088119:c1160920-1160546 [Enterobacter kobei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT226655 NZ_CP122588:4160636-4160827 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W0G488

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References