Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 1006662..1007341 | Replicon | chromosome |
| Accession | NZ_CP088119 | ||
| Organism | Enterobacter kobei strain 6 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | LRM31_RS04815 | Protein ID | WP_000854680.1 |
| Coordinates | 1006662..1007003 (-) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | LRM31_RS04820 | Protein ID | WP_000070396.1 |
| Coordinates | 1007024..1007341 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LRM31_RS04785 (LRM31_04785) | 1001721..1002071 | + | 351 | WP_032102837.1 | hypothetical protein | - |
| LRM31_RS04790 (LRM31_04790) | 1002095..1003135 | + | 1041 | WP_032102839.1 | major capsid protein | - |
| LRM31_RS04795 (LRM31_04795) | 1003200..1003406 | + | 207 | WP_208557534.1 | hypothetical protein | - |
| LRM31_RS04800 (LRM31_04800) | 1003427..1004191 | - | 765 | WP_223866203.1 | hypothetical protein | - |
| LRM31_RS04805 (LRM31_04805) | 1004139..1004780 | - | 642 | WP_032102845.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LRM31_RS04810 (LRM31_04810) | 1004927..1006129 | - | 1203 | WP_208557533.1 | site-specific integrase | - |
| LRM31_RS04815 (LRM31_04815) | 1006662..1007003 | - | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| LRM31_RS04820 (LRM31_04820) | 1007024..1007341 | - | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| LRM31_RS04825 (LRM31_04825) | 1007360..1007581 | - | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| LRM31_RS04830 (LRM31_04830) | 1007590..1008066 | - | 477 | WP_000811693.1 | RadC family protein | - |
| LRM31_RS04835 (LRM31_04835) | 1008082..1008540 | - | 459 | WP_000211838.1 | antirestriction protein | - |
| LRM31_RS04840 (LRM31_04840) | 1008638..1008877 | - | 240 | WP_000194654.1 | DUF905 family protein | - |
| LRM31_RS04845 (LRM31_04845) | 1008954..1009421 | - | 468 | WP_032200803.1 | protein YkfB | - |
| LRM31_RS04850 (LRM31_04850) | 1009444..1009887 | - | 444 | WP_048976522.1 | lipoprotein YafY | - |
| LRM31_RS04855 (LRM31_04855) | 1009887..1010123 | - | 237 | WP_001144031.1 | protein YpjK | - |
| LRM31_RS04860 (LRM31_04860) | 1010164..1010865 | - | 702 | WP_241448995.1 | WYL domain-containing protein | - |
| LRM31_RS04865 (LRM31_04865) | 1011082..1011903 | - | 822 | WP_241448996.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 992806..1009421 | 16615 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T226654 WP_000854680.1 NZ_CP088119:c1007003-1006662 [Enterobacter kobei]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T226654 NZ_CP122588:3997521-3997799 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGCTCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT226654 WP_000070396.1 NZ_CP088119:c1007341-1007024 [Enterobacter kobei]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT226654 NZ_CP122588:3997258-3997518 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGGTGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|