226651

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 71879..72558 Replicon chromosome
Accession NZ_CP088119
Organism Enterobacter kobei strain 6

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LRM31_RS00370 Protein ID WP_032170241.1
Coordinates 71879..72220 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A855M3D0
Locus tag LRM31_RS00375 Protein ID WP_032170240.1
Coordinates 72241..72558 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRM31_RS00350 (LRM31_00350) 67101..68036 + 936 WP_241448938.1 DUF1837 domain-containing protein -
LRM31_RS00355 (LRM31_00355) 68038..70224 + 2187 WP_241448939.1 DEAD/DEAH box helicase -
LRM31_RS00360 (LRM31_00360) 70429..70812 - 384 WP_032170243.1 hypothetical protein -
LRM31_RS00365 (LRM31_00365) 70885..71586 + 702 WP_032170242.1 toll/interleukin-1 receptor domain-containing protein -
LRM31_RS00370 (LRM31_00370) 71879..72220 - 342 WP_032170241.1 TA system toxin CbtA family protein Toxin
LRM31_RS00375 (LRM31_00375) 72241..72558 - 318 WP_032170240.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LRM31_RS00380 (LRM31_00380) 72577..72798 - 222 WP_000691995.1 DUF987 domain-containing protein -
LRM31_RS00385 (LRM31_00385) 72807..73283 - 477 WP_001618788.1 RadC family protein -
LRM31_RS00390 (LRM31_00390) 73299..73757 - 459 WP_000211838.1 antirestriction protein -
LRM31_RS00395 (LRM31_00395) 73855..74094 - 240 WP_032170520.1 DUF905 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12821.81 Da        Isoelectric Point: 10.0426

>T226651 WP_032170241.1 NZ_CP088119:c72220-71879 [Enterobacter kobei]
MKILPATTSRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIQNHINAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRQSRNTAVR

Download         Length: 342 bp

>T226651 NZ_CP122588:2803620-2803727 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11849.44 Da        Isoelectric Point: 6.7373

>AT226651 WP_032170240.1 NZ_CP088119:c72558-72241 [Enterobacter kobei]
MSNITWGLQRNITPCLGARLVQEGNRLHYLADRTSITGKFSDAECFKLDVAFPHFISQMESMLTTGEMNPHHAHYVILYH
NGFTCEADTLGSCGYVYVAVYSTQR

Download         Length: 318 bp

>AT226651 NZ_CP122588:c2803573-2803507 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A855M3D0

References