Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1220772..1221442 Replicon plasmid pRRI128_2
Accession NZ_CP088115
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name vapC Uniprot ID A0A6A7ZLT1
Locus tag SmelRRI128_RS31270 Protein ID WP_017276662.1
Coordinates 1220772..1221191 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6A7ZM99
Locus tag SmelRRI128_RS31275 Protein ID WP_015242681.1
Coordinates 1221188..1221442 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS31250 (SmelRRI128_31250) 1215834..1216994 + 1161 WP_027989447.1 GGDEF domain-containing protein -
SmelRRI128_RS31255 (SmelRRI128_31255) 1217051..1217413 - 363 WP_015242677.1 response regulator -
SmelRRI128_RS31260 (SmelRRI128_31260) 1217441..1219975 - 2535 WP_017276664.1 PAS domain S-box protein -
SmelRRI128_RS31265 (SmelRRI128_31265) 1220375..1220803 + 429 WP_017276663.1 GFA family protein -
SmelRRI128_RS31270 (SmelRRI128_31270) 1220772..1221191 - 420 WP_017276662.1 type II toxin-antitoxin system VapC family toxin Toxin
SmelRRI128_RS31275 (SmelRRI128_31275) 1221188..1221442 - 255 WP_015242681.1 plasmid stability protein Antitoxin
SmelRRI128_RS31280 (SmelRRI128_31280) 1221635..1222597 - 963 WP_017276661.1 ATP-binding cassette domain-containing protein -
SmelRRI128_RS31285 (SmelRRI128_31285) 1222594..1223508 - 915 WP_027989448.1 ABC transporter ATP-binding protein -
SmelRRI128_RS31290 (SmelRRI128_31290) 1223505..1224326 - 822 WP_027989449.1 ABC transporter permease -
SmelRRI128_RS31295 (SmelRRI128_31295) 1224332..1225267 - 936 WP_027989450.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1289339 1289339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14688.94 Da        Isoelectric Point: 7.3177

>T226649 WP_017276662.1 NZ_CP088115:c1221191-1220772 [Sinorhizobium meliloti]
MIVLGTNVVSEAMKPTPDPAVRSWLNEQVAETLYLASVTLAELLFGIGALPDGRRKKALTEMLGGVLELFGDRVLPFDIG
AARHYAELAVTARAAGKGFPTADGYIAAIAASRGFIVATRDSSPFGAAGLTVVNPWHHR

Download         Length: 420 bp

>T226649 NZ_CP122588:2474921-2476243 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACTTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTAGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGGGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGGTATG
ATTTTATGAAATTCCAGGTCTTTCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGGATACACAT
CAGCGATCTCAAACTGGCAATGGGACTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCAGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9480.82 Da        Isoelectric Point: 6.4732

>AT226649 WP_015242681.1 NZ_CP088115:c1221442-1221188 [Sinorhizobium meliloti]
MAILTVRNVPDEVHRALRVRAAMHGRSTEAEVREILESAVKPEQRVRMGDALAELGRRLGLTNDDFAVFDEVRDKAPAQP
VRFE

Download         Length: 255 bp

>AT226649 NZ_CP122588:2474655-2474921 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCAGACAATACCACGC
TGACGACCTTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A7ZLT1

Antitoxin

Source ID Structure
AlphaFold DB A0A6A7ZM99

References