226648

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1092469..1093049 Replicon plasmid pRRI128_2
Accession NZ_CP088115
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name vapC Uniprot ID Q92XP1
Locus tag SmelRRI128_RS30615 Protein ID WP_010968151.1
Coordinates 1092666..1093049 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6A7ZSC9
Locus tag SmelRRI128_RS30610 Protein ID WP_027989394.1
Coordinates 1092469..1092669 (+) Length 67 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS30595 (SmelRRI128_30595) 1089980..1090975 + 996 WP_027990925.1 SLAC1 anion channel family protein -
SmelRRI128_RS30600 (SmelRRI128_30600) 1090975..1091934 + 960 WP_015242578.1 GlxA family transcriptional regulator -
SmelRRI128_RS30605 (SmelRRI128_30605) 1092029..1092274 + 246 WP_014532040.1 membrane protein -
SmelRRI128_RS30610 (SmelRRI128_30610) 1092469..1092669 + 201 WP_027989394.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SmelRRI128_RS30615 (SmelRRI128_30615) 1092666..1093049 + 384 WP_010968151.1 type II toxin-antitoxin system VapC family toxin Toxin
SmelRRI128_RS30620 (SmelRRI128_30620) 1093497..1093892 + 396 WP_027989395.1 response regulator -
SmelRRI128_RS30625 (SmelRRI128_30625) 1094176..1094487 - 312 WP_027989396.1 hypothetical protein -
SmelRRI128_RS30630 (SmelRRI128_30630) 1094820..1095656 + 837 WP_015242582.1 TIGR02587 family membrane protein -
SmelRRI128_RS30635 (SmelRRI128_30635) 1095653..1096099 + 447 WP_027989397.1 TIGR02588 family protein -
SmelRRI128_RS30640 (SmelRRI128_30640) 1096269..1096673 - 405 WP_015242584.1 MerR family DNA-binding protein -
SmelRRI128_RS30645 (SmelRRI128_30645) 1096728..1097516 + 789 WP_014532050.1 glutaredoxin family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1289339 1289339


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-113)

Antitoxin

(1-42)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14292.54 Da        Isoelectric Point: 6.9172

>T226648 WP_010968151.1 NZ_CP088115:1092666-1093049 [Sinorhizobium meliloti]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN

Download         Length: 384 bp

>T226648 NZ_CP122588:2400450-2400737 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7097.16 Da        Isoelectric Point: 10.4525

>AT226648 WP_027989394.1 NZ_CP088115:1092469-1092669 [Sinorhizobium meliloti]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAE

Download         Length: 201 bp

>AT226648 NZ_CP122588:2400211-2400450 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q92XP1


Antitoxin

Source ID Structure
AlphaFold DB A0A6A7ZSC9

References