Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1092469..1093049 | Replicon | plasmid pRRI128_2 |
Accession | NZ_CP088115 | ||
Organism | Sinorhizobium meliloti strain RRI128 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | Q92XP1 |
Locus tag | SmelRRI128_RS30615 | Protein ID | WP_010968151.1 |
Coordinates | 1092666..1093049 (+) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A6A7ZSC9 |
Locus tag | SmelRRI128_RS30610 | Protein ID | WP_027989394.1 |
Coordinates | 1092469..1092669 (+) | Length | 67 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SmelRRI128_RS30595 (SmelRRI128_30595) | 1089980..1090975 | + | 996 | WP_027990925.1 | SLAC1 anion channel family protein | - |
SmelRRI128_RS30600 (SmelRRI128_30600) | 1090975..1091934 | + | 960 | WP_015242578.1 | GlxA family transcriptional regulator | - |
SmelRRI128_RS30605 (SmelRRI128_30605) | 1092029..1092274 | + | 246 | WP_014532040.1 | membrane protein | - |
SmelRRI128_RS30610 (SmelRRI128_30610) | 1092469..1092669 | + | 201 | WP_027989394.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
SmelRRI128_RS30615 (SmelRRI128_30615) | 1092666..1093049 | + | 384 | WP_010968151.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
SmelRRI128_RS30620 (SmelRRI128_30620) | 1093497..1093892 | + | 396 | WP_027989395.1 | response regulator | - |
SmelRRI128_RS30625 (SmelRRI128_30625) | 1094176..1094487 | - | 312 | WP_027989396.1 | hypothetical protein | - |
SmelRRI128_RS30630 (SmelRRI128_30630) | 1094820..1095656 | + | 837 | WP_015242582.1 | TIGR02587 family membrane protein | - |
SmelRRI128_RS30635 (SmelRRI128_30635) | 1095653..1096099 | + | 447 | WP_027989397.1 | TIGR02588 family protein | - |
SmelRRI128_RS30640 (SmelRRI128_30640) | 1096269..1096673 | - | 405 | WP_015242584.1 | MerR family DNA-binding protein | - |
SmelRRI128_RS30645 (SmelRRI128_30645) | 1096728..1097516 | + | 789 | WP_014532050.1 | glutaredoxin family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | htpB | 1..1289339 | 1289339 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14292.54 Da Isoelectric Point: 6.9172
>T226648 WP_010968151.1 NZ_CP088115:1092666-1093049 [Sinorhizobium meliloti]
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN
VILADTSIWIDHFRHTDAELRRIIEDDRLLCHPAVIGELALGSLRERSSVIAFLMAQREALVATHQEVMMMIDRHAIFSM
GIGYTDAHLLASVLLDQRMALWTRDKRLQAAAEKAGASLHTPAHTRN
Download Length: 384 bp
>T226648 NZ_CP122588:2400450-2400737 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 67 a.a. Molecular weight: 7097.16 Da Isoelectric Point: 10.4525
>AT226648 WP_027989394.1 NZ_CP088115:1092469-1092669 [Sinorhizobium meliloti]
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAE
MRSTINLDDTLMERAKSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSAAAE
Download Length: 201 bp
>AT226648 NZ_CP122588:2400211-2400450 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q92XP1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6A7ZSC9 |