Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2604636..2605267 Replicon chromosome
Accession NZ_CP088113
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SmelRRI128_RS12905 Protein ID WP_013844828.1
Coordinates 2604636..2605034 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q92MD9
Locus tag SmelRRI128_RS12910 Protein ID WP_010970129.1
Coordinates 2605034..2605267 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS12870 (SmelRRI128_12870) 2599718..2600020 - 303 WP_027989813.1 type II toxin-antitoxin system RelE/ParE family toxin -
SmelRRI128_RS12875 (SmelRRI128_12875) 2600017..2600292 - 276 WP_027989812.1 type II toxin-antitoxin system ParD family antitoxin -
SmelRRI128_RS12880 (SmelRRI128_12880) 2600578..2600727 + 150 WP_027989811.1 hypothetical protein -
SmelRRI128_RS12885 (SmelRRI128_12885) 2600724..2601659 + 936 WP_027989810.1 site-specific tyrosine recombinase XerD -
SmelRRI128_RS12890 (SmelRRI128_12890) 2601723..2602676 + 954 WP_003527479.1 acetyl-CoA carboxylase carboxyltransferase subunit alpha -
SmelRRI128_RS12895 (SmelRRI128_12895) 2602921..2604363 + 1443 WP_027989809.1 murein L,D-transpeptidase family protein -
SmelRRI128_RS12900 (SmelRRI128_12900) 2604363..2604602 + 240 WP_010970127.1 sulfurtransferase TusA family protein -
SmelRRI128_RS12905 (SmelRRI128_12905) 2604636..2605034 - 399 WP_013844828.1 type II toxin-antitoxin system toxin VapC Toxin
SmelRRI128_RS12910 (SmelRRI128_12910) 2605034..2605267 - 234 WP_010970129.1 type II toxin-antitoxin system antitoxin VapB Antitoxin
SmelRRI128_RS12915 (SmelRRI128_12915) 2605376..2606521 - 1146 WP_027989808.1 GTP-binding protein -
SmelRRI128_RS12920 (SmelRRI128_12920) 2606535..2607617 - 1083 WP_231198577.1 D-alanyl-D-alanine carboxypeptidase family protein -
SmelRRI128_RS12925 (SmelRRI128_12925) 2607869..2609032 + 1164 WP_027989806.1 M20 aminoacylase family protein -
SmelRRI128_RS12930 (SmelRRI128_12930) 2609055..2609519 + 465 WP_010970133.1 Lrp/AsnC ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14829.13 Da        Isoelectric Point: 6.9581

>T226641 WP_013844828.1 NZ_CP088113:c2605034-2604636 [Sinorhizobium meliloti]
MLTYMLDTNICIYVMKTYPPAVREKFNGLAEQLCISSITLGELHYGAEKSARRVENLTAIEHFVARLEVLPFADKAAAHY
GQVRAELERTGTPCGPHDMQIGAHARSEGLIVVTNNIREFVRMPGVRVENWL

Download         Length: 399 bp

>T226641 NZ_CP122588:220988-221095 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8673.87 Da        Isoelectric Point: 8.9167

>AT226641 WP_010970129.1 NZ_CP088113:c2605267-2605034 [Sinorhizobium meliloti]
MASSTVFISNRSQAVRLPKAVAFPEGVHQVDILKIGRSRVIVPQGKRWDDLFLSGPRVSEDFMSERDQPVAETRESF

Download         Length: 234 bp

>AT226641 NZ_CP122588:c220940-220874 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q92MD9

References