Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 2509042..2509808 Replicon chromosome
Accession NZ_CP088113
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag SmelRRI128_RS12300 Protein ID WP_027990219.1
Coordinates 2509326..2509808 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID H0G6D4
Locus tag SmelRRI128_RS12295 Protein ID WP_003533490.1
Coordinates 2509042..2509326 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS12280 (SmelRRI128_12280) 2504485..2505900 + 1416 WP_014529872.1 lipopolysaccharide biosynthesis protein -
SmelRRI128_RS12285 (SmelRRI128_12285) 2505904..2507175 + 1272 WP_010970087.1 GNAT family N-acetyltransferase -
SmelRRI128_RS12290 (SmelRRI128_12290) 2507191..2508837 - 1647 WP_027990220.1 AMP-binding protein -
SmelRRI128_RS12295 (SmelRRI128_12295) 2509042..2509326 + 285 WP_003533490.1 DUF1778 domain-containing protein Antitoxin
SmelRRI128_RS12300 (SmelRRI128_12300) 2509326..2509808 + 483 WP_027990219.1 GNAT family N-acetyltransferase Toxin
SmelRRI128_RS12305 (SmelRRI128_12305) 2509879..2510046 + 168 WP_155247989.1 hypothetical protein -
SmelRRI128_RS12310 (SmelRRI128_12310) 2510243..2510416 + 174 WP_155247988.1 hypothetical protein -
SmelRRI128_RS12315 (SmelRRI128_12315) 2510493..2510729 + 237 WP_027990218.1 hypothetical protein -
SmelRRI128_RS12320 (SmelRRI128_12320) 2510738..2511604 + 867 WP_050579950.1 nucleotide-binding protein -
SmelRRI128_RS12325 (SmelRRI128_12325) 2512775..2513803 - 1029 WP_155247987.1 DUF2971 domain-containing protein -
SmelRRI128_RS12330 (SmelRRI128_12330) 2513957..2514322 + 366 WP_027990216.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-142)

Antitoxin

Vibrio phage ICP1, Orf50

(1-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17419.87 Da        Isoelectric Point: 7.9232

>T226640 WP_027990219.1 NZ_CP088113:2509326-2509808 [Sinorhizobium meliloti]
MLSAPTPLGEAHDFDLFQSGNATLDDWLRRRAHANQASGASRTYVIAEEWRVVGYYCLASGALDLADAPSSVRRNMPDPI
PMAVLGRLAIDRDWQGKGLGAALLQDAVLRSSQAADIMGIRGLLVHAISGEAKAFYEHYGFQCSPNHPMTLVLSLKGKRR

Download         Length: 483 bp

>T226640 NZ_CP122588:220505-220612 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10771.12 Da        Isoelectric Point: 7.3175

>AT226640 WP_003533490.1 NZ_CP088113:2509042-2509326 [Sinorhizobium meliloti]
MATKSSTDTHAKPVNLRIREDIRKVIDRAASIRGKTRSDFMIDAAYRAAEDTLLDQTLVRVDEHSYRHYLDILDQPPSGD
GFERLMNAPKPWQS

Download         Length: 285 bp

>AT226640 NZ_CP122588:c220457-220391 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0G6D4

References