226639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 2275694..2276367 Replicon chromosome
Accession NZ_CP088113
Organism Sinorhizobium meliloti strain RRI128

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SmelRRI128_RS11165 Protein ID WP_010969926.1
Coordinates 2275963..2276367 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID H0GA10
Locus tag SmelRRI128_RS11160 Protein ID WP_003536345.1
Coordinates 2275694..2275966 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SmelRRI128_RS11140 (SmelRRI128_11140) 2271685..2273325 - 1641 WP_027990609.1 ABC transporter substrate-binding protein -
SmelRRI128_RS11145 (SmelRRI128_11145) 2273373..2274428 - 1056 WP_027990610.1 dipeptidase -
SmelRRI128_RS11150 (SmelRRI128_11150) 2274608..2274949 - 342 WP_003536339.1 SMR family transporter -
SmelRRI128_RS11155 (SmelRRI128_11155) 2274997..2275557 - 561 WP_027990611.1 TetR/AcrR family transcriptional regulator -
SmelRRI128_RS11160 (SmelRRI128_11160) 2275694..2275966 + 273 WP_003536345.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SmelRRI128_RS11165 (SmelRRI128_11165) 2275963..2276367 + 405 WP_010969926.1 type II toxin-antitoxin system VapC family toxin Toxin
SmelRRI128_RS11170 (SmelRRI128_11170) 2276495..2276887 + 393 WP_027990612.1 globin -
SmelRRI128_RS11175 (SmelRRI128_11175) 2276893..2277267 + 375 WP_027990613.1 DUF423 domain-containing protein -
SmelRRI128_RS11180 (SmelRRI128_11180) 2277390..2277650 + 261 WP_027990614.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SmelRRI128_RS11185 (SmelRRI128_11185) 2277766..2278080 - 315 WP_003536354.1 antibiotic biosynthesis monooxygenase -
SmelRRI128_RS11190 (SmelRRI128_11190) 2278363..2278629 - 267 WP_027990615.1 hypothetical protein -
SmelRRI128_RS11195 (SmelRRI128_11195) 2278682..2279095 - 414 WP_027990616.1 DUF2325 domain-containing protein -
SmelRRI128_RS11200 (SmelRRI128_11200) 2279301..2280227 - 927 WP_027990617.1 energy transducer TonB -
SmelRRI128_RS11205 (SmelRRI128_11205) 2280268..2280702 - 435 WP_027990618.1 hypothetical protein -
SmelRRI128_RS11210 (SmelRRI128_11210) 2280932..2281072 + 141 WP_027990619.1 hemin uptake protein HemP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(16-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14747.98 Da        Isoelectric Point: 5.1974

>T226639 WP_010969926.1 NZ_CP088113:2275963-2276367 [Sinorhizobium meliloti]
MNGYLLDTNIISDVIHNPFGPAAQRIERIGPKEIYTSIVVASELRYGCAKKGSAKLLAKVESLLEIVPVLPLDIPADTRY
GSIRAELESLGQTIGSNDLLIAAHAYALDLTLVTDNIREFSRVRGLSLENWLER

Download         Length: 405 bp

>T226639 NZ_CP122588:220022-220129 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10334.02 Da        Isoelectric Point: 6.3950

>AT226639 WP_003536345.1 NZ_CP088113:2275694-2275966 [Sinorhizobium meliloti]
MPVPLPSSRPKEVKLFRNNRSQAVRIPAEFELPGDRVLIRREGTRLIIEPIARPADIVELLAEWKKEAPLGPEDRFPDVE
DIPARPEKIF

Download         Length: 273 bp

>AT226639 NZ_CP122588:c219974-219908 [Escherichia coli]
GGTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0GA10

References