Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT_toxin-BrnA |
| Location | 239124..239701 | Replicon | chromosome |
| Accession | NZ_CP088113 | ||
| Organism | Sinorhizobium meliloti strain RRI128 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | Q92S20 |
| Locus tag | SmelRRI128_RS01115 | Protein ID | WP_010968707.1 |
| Coordinates | 239124..239387 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | Q92KN5 |
| Locus tag | SmelRRI128_RS01120 | Protein ID | WP_010968708.1 |
| Coordinates | 239384..239701 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SmelRRI128_RS01075 (SmelRRI128_01075) | 234453..234893 | + | 441 | WP_010968702.1 | DUF2948 family protein | - |
| SmelRRI128_RS01080 (SmelRRI128_01080) | 234958..236262 | + | 1305 | WP_010968703.1 | histidinol dehydrogenase | - |
| SmelRRI128_RS01085 (SmelRRI128_01085) | 236259..236735 | + | 477 | WP_010968704.1 | UPF0262 family protein | - |
| SmelRRI128_RS01090 (SmelRRI128_01090) | 236749..237228 | + | 480 | WP_010968705.1 | low molecular weight phosphatase family protein | - |
| SmelRRI128_RS01095 (SmelRRI128_01095) | 237386..237604 | + | 219 | WP_004435948.1 | translation initiation factor IF-1 | - |
| SmelRRI128_RS01100 (SmelRRI128_01100) | 237702..238322 | + | 621 | WP_004435951.1 | Maf-like protein | - |
| SmelRRI128_RS01105 (SmelRRI128_01105) | 238327..238539 | + | 213 | WP_010968706.1 | DNA gyrase inhibitor YacG | - |
| SmelRRI128_RS01115 (SmelRRI128_01115) | 239124..239387 | + | 264 | WP_010968707.1 | BrnT family toxin | Toxin |
| SmelRRI128_RS01120 (SmelRRI128_01120) | 239384..239701 | + | 318 | WP_010968708.1 | BrnA antitoxin family protein | Antitoxin |
| SmelRRI128_RS01125 (SmelRRI128_01125) | 239903..240367 | - | 465 | WP_013844019.1 | type II toxin-antitoxin system HicB family antitoxin | - |
| SmelRRI128_RS01130 (SmelRRI128_01130) | 240364..240552 | - | 189 | WP_013844020.1 | hypothetical protein | - |
| SmelRRI128_RS01135 (SmelRRI128_01135) | 240872..241972 | + | 1101 | WP_010968710.1 | hypothetical protein | - |
| SmelRRI128_RS01140 (SmelRRI128_01140) | 241959..243041 | + | 1083 | WP_010968711.1 | nucleotidyltransferase family protein | - |
| SmelRRI128_RS01145 (SmelRRI128_01145) | 243244..243555 | + | 312 | WP_004435964.1 | hypothetical protein | - |
| SmelRRI128_RS01150 (SmelRRI128_01150) | 243835..244224 | - | 390 | WP_013844021.1 | DUF930 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 9821.16 Da Isoelectric Point: 10.3413
>T226635 WP_010968707.1 NZ_CP088113:239124-239387 [Sinorhizobium meliloti]
MRIVWGEPKRRANLEKHGFDFADVSDLDWASALIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP
MRIVWGEPKRRANLEKHGFDFADVSDLDWASALIEDSKPDTSGRKRLKAIGYFRDGTAAVIFATLGTEAISIISFRPASD
RERRRLP
Download Length: 264 bp
>T226635 NZ_CP122587:c4720608-4720075 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 106 a.a. Molecular weight: 12197.83 Da Isoelectric Point: 10.0883
>AT226635 WP_010968708.1 NZ_CP088113:239384-239701 [Sinorhizobium meliloti]
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI
MTTRTRKSKTFEPGHGYTKEEWDAVDFPELTDEELTNMRPARDVLPPEFFKAMEEHRRSRGRPSLEHPKKQVTLRLDEDV
IAKFRAGGKGWQSRMNEALRKAAGI
Download Length: 318 bp
>AT226635 NZ_CP122587:c4720885-4720619 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|