Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 409623..410203 Replicon plasmid pTA1_4
Accession NZ_CP088108
Organism Rhizobium ruizarguesonis strain TA1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegTA1_RS36540 Protein ID WP_027688371.1
Coordinates 409820..410203 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RlegTA1_RS36535 Protein ID WP_027688372.1
Coordinates 409623..409823 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegTA1_RS36495 (RlegTA1_36495) 404798..405556 - 759 WP_027688378.1 ImuA family protein -
RlegTA1_RS36500 (RlegTA1_36500) 405731..405994 + 264 WP_027688377.1 hypothetical protein -
RlegTA1_RS36505 (RlegTA1_36505) 405998..406630 + 633 WP_231286905.1 DNA polymerase IV -
RlegTA1_RS36510 (RlegTA1_36510) 406546..406992 + 447 Protein_438 DNA polymerase IV -
RlegTA1_RS36515 (RlegTA1_36515) 407323..407931 - 609 WP_231286906.1 hypothetical protein -
RlegTA1_RS36520 (RlegTA1_36520) 408059..408316 + 258 WP_027688375.1 CrpP-related protein -
RlegTA1_RS36525 (RlegTA1_36525) 408714..409157 - 444 WP_027688374.1 GNAT family N-acetyltransferase -
RlegTA1_RS36530 (RlegTA1_36530) 409374..409596 - 223 Protein_442 hypothetical protein -
RlegTA1_RS36535 (RlegTA1_36535) 409623..409823 + 201 WP_027688372.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RlegTA1_RS36540 (RlegTA1_36540) 409820..410203 + 384 WP_027688371.1 type II toxin-antitoxin system VapC family toxin Toxin
RlegTA1_RS36545 (RlegTA1_36545) 410503..411393 - 891 WP_027688370.1 LysR family transcriptional regulator -
RlegTA1_RS36550 (RlegTA1_36550) 411491..411826 + 336 WP_085065853.1 helix-turn-helix transcriptional regulator -
RlegTA1_RS36555 (RlegTA1_36555) 412084..412650 - 567 WP_027688369.1 hypothetical protein -
RlegTA1_RS36560 (RlegTA1_36560) 412647..413825 - 1179 WP_231286907.1 ATP-binding protein -
RlegTA1_RS36565 (RlegTA1_36565) 413949..414107 + 159 WP_156925142.1 hypothetical protein -
RlegTA1_RS36570 (RlegTA1_36570) 414254..414754 - 501 Protein_450 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..504966 504966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14229.45 Da        Isoelectric Point: 8.1753

>T226629 WP_027688371.1 NZ_CP088108:409820-410203 [Rhizobium ruizarguesonis]
VILADTSIWSDHFRHMNAELRWVIEGDRLLCHPSVIGELALGSLRDRRSVLAFLTAQRKAIVATHDEVMTMIDRHGIFSM
GIGYTDAHLLASVLLEQRAALWTRDKRLRAAAEKAGAALHIPVDRSH

Download         Length: 384 bp

>T226629 NZ_CP122587:350415-350762 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7110.18 Da        Isoelectric Point: 11.1107

>AT226629 WP_027688372.1 NZ_CP088108:409623-409823 [Rhizobium ruizarguesonis]
MRSTINLDDTLLDKARSLTGTKETAALVRQALETLVRVESGKRLIALGGTMPDAEAAPRRRSTASK

Download         Length: 201 bp

>AT226629 NZ_CP122587:350762-351061 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References