Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 270500..271176 Replicon plasmid pTA1_1
Accession NZ_CP088105
Organism Rhizobium ruizarguesonis strain TA1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegTA1_RS26060 Protein ID WP_027688084.1
Coordinates 270751..271176 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4Q8ZXM1
Locus tag RlegTA1_RS26055 Protein ID WP_075224380.1
Coordinates 270500..270754 (+) Length 85 a.a.

Genomic Context

RlegTA1_RS26035RlegTA1_RS26050RlegTA1_RS26055RlegTA1_RS26060RlegTA1_RS26065RlegTA1_RS26075RlegTA1_RS26080RlegTA1_RS26025RlegTA1_RS26030RlegTA1_RS26040RlegTA1_RS26045RlegTA1_RS26070
Location: 267672..267842 (171 bp)
Type: Others
Protein ID: WP_231286869.1
Location: 269769..270344 (576 bp)
Type: Others
Protein ID: WP_018480381.1
Location: 270500..270754 (255 bp)
Type: Antitoxin
Protein ID: WP_075224380.1
Location: 270751..271176 (426 bp)
Type: Toxin
Protein ID: WP_027688084.1
Location: 271622..272410 (789 bp)
Type: Others
Protein ID: WP_027688083.1
Location: 273593..275470 (1878 bp)
Type: Others
Protein ID: WP_024321535.1
Location: 275667..276056 (390 bp)
Type: Others
Protein ID: WP_027688081.1
Location: 265854..266747 (894 bp)
Type: Others
Protein ID: WP_027688088.1
Location: 266815..267240 (426 bp)
Type: Others
Protein ID: WP_027688087.1
Location: 267916..268881 (966 bp)
Type: Others
Protein ID: WP_027688086.1
Location: 268978..269664 (687 bp)
Type: Others
Protein ID: WP_027688085.1
Location: 272528..273205 (678 bp)
Type: Others
Protein ID: Protein_256
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RlegTA1_RS26025 (RlegTA1_26025)265854..266747-894WP_027688088.1NmrA family NAD(P)-binding protein-
RlegTA1_RS26030 (RlegTA1_26030)266815..267240-426WP_027688087.1MarR family winged helix-turn-helix transcriptional regulator-
RlegTA1_RS26035 (RlegTA1_26035)267672..267842+171WP_231286869.1hypothetical protein-
RlegTA1_RS26040 (RlegTA1_26040)267916..268881-966WP_027688086.1alpha/beta hydrolase-
RlegTA1_RS26045 (RlegTA1_26045)268978..269664-687WP_027688085.1glutathione S-transferase-
RlegTA1_RS26050 (RlegTA1_26050)269769..270344+576WP_018480381.1TetR/AcrR family transcriptional regulator-
RlegTA1_RS26055 (RlegTA1_26055)270500..270754+255WP_075224380.1plasmid stabilization proteinAntitoxin
RlegTA1_RS26060 (RlegTA1_26060)270751..271176+426WP_027688084.1type II toxin-antitoxin system VapC family toxinToxin
RlegTA1_RS26065 (RlegTA1_26065)271622..272410+789WP_027688083.1siderophore-iron reductase FhuF-
RlegTA1_RS26070 (RlegTA1_26070)272528..273205-678Protein_256phosphopantetheinyl transferase-
RlegTA1_RS26075 (RlegTA1_26075)273593..275470+1878WP_024321535.1HAMP domain-containing methyl-accepting chemotaxis protein-
RlegTA1_RS26080 (RlegTA1_26080)275667..276056+390WP_027688081.1RidA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..805037805037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15186.42 Da        Isoelectric Point: 4.8283

>T226626 WP_027688084.1 NZ_CP088105:270751-271176 [Rhizobium ruizarguesonis]
MILIDTNVISEPWKPTPDNQVLAWIDAQAVETLFVSAITVAELRFGIAAMPSGRRKTVLDDRLEQEVLPLFSGRVLSFDM
AASQSYSELMARARAAGRAIGKADAYIAATAAANGFIVATRDSSPFEAAGLKVINPWYAPT

Download         Length: 426 bp

>T226626 NZ_CP122583:c6121-5816 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9249.43 Da        Isoelectric Point: 5.6158

>AT226626 WP_075224380.1 NZ_CP088105:270500-270754 [Rhizobium ruizarguesonis]
MAAVTIRNLSDETHRALRVRAAHHGRSTEAEIRDILETAVRPAERVMLGSLLASIGREAGLSNDDVDNLQLVRDKTPAEP
MSFE

Download         Length: 255 bp

>AT226626 NZ_CP122583:c6341-6123 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4Q8ZXM1

References