Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 60974..61665 Replicon plasmid pTA1_1
Accession NZ_CP088105
Organism Rhizobium ruizarguesonis strain TA1

Toxin (Protein)


Gene name vapC Uniprot ID A0A4Q8ZX68
Locus tag RlegTA1_RS25080 Protein ID WP_027688184.1
Coordinates 60974..61402 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R0AD13
Locus tag RlegTA1_RS25085 Protein ID WP_017991284.1
Coordinates 61399..61665 (-) Length 89 a.a.

Genomic Context

RlegTA1_RS25060RlegTA1_RS25065RlegTA1_RS25070RlegTA1_RS25075RlegTA1_RS25090RlegTA1_RS25095RlegTA1_RS25100RlegTA1_RS25105RlegTA1_RS25110RlegTA1_RS25080RlegTA1_RS25085
Location: 57869..58708 (840 bp)
Type: Others
Protein ID: WP_027688185.1
Location: 58826..59488 (663 bp)
Type: Others
Protein ID: WP_003550217.1
Location: 59495..60154 (660 bp)
Type: Others
Protein ID: WP_024319797.1
Location: 60167..60937 (771 bp)
Type: Others
Protein ID: WP_018480586.1
Location: 61922..62665 (744 bp)
Type: Others
Protein ID: WP_027688183.1
Location: 62669..63454 (786 bp)
Type: Others
Protein ID: WP_024319800.1
Location: 63536..64207 (672 bp)
Type: Others
Protein ID: WP_024319801.1
Location: 64204..64863 (660 bp)
Type: Others
Protein ID: WP_024319802.1
Location: 64841..65566 (726 bp)
Type: Others
Protein ID: WP_024319803.1
Location: 60974..61402 (429 bp)
Type: Toxin
Protein ID: WP_027688184.1
Location: 61399..61665 (267 bp)
Type: Antitoxin
Protein ID: WP_017991284.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RlegTA1_RS25060 (RlegTA1_25060)57869..58708+840WP_027688185.1transporter substrate-binding domain-containing protein-
RlegTA1_RS25065 (RlegTA1_25065)58826..59488+663WP_003550217.1amino acid ABC transporter permease-
RlegTA1_RS25070 (RlegTA1_25070)59495..60154+660WP_024319797.1amino acid ABC transporter permease-
RlegTA1_RS25075 (RlegTA1_25075)60167..60937+771WP_018480586.1amino acid ABC transporter ATP-binding protein-
RlegTA1_RS25080 (RlegTA1_25080)60974..61402-429WP_027688184.1type II toxin-antitoxin system VapC family toxinToxin
RlegTA1_RS25085 (RlegTA1_25085)61399..61665-267WP_017991284.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
RlegTA1_RS25090 (RlegTA1_25090)61922..62665+744WP_027688183.1GntR family transcriptional regulator-
RlegTA1_RS25095 (RlegTA1_25095)62669..63454+786WP_024319800.1transporter substrate-binding domain-containing protein-
RlegTA1_RS25100 (RlegTA1_25100)63536..64207+672WP_024319801.1amino acid ABC transporter permease-
RlegTA1_RS25105 (RlegTA1_25105)64204..64863+660WP_024319802.1amino acid ABC transporter permease-
RlegTA1_RS25110 (RlegTA1_25110)64841..65566+726WP_024319803.1amino acid ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..805037805037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-66)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15824.14 Da        Isoelectric Point: 4.7948

>T226625 WP_027688184.1 NZ_CP088105:c61402-60974 [Rhizobium ruizarguesonis]
VRLLLDTNVLSEVTRPRPDAHVLQWLDDLDEDRSFISVVSIAEIRRGVALMESGRKRDALAEWLAQDLPQRFEQRVIPVD
QAVAITWGDLMGLAKRSGRGLSSMGGLIAATAIAHDLTLATRNIKDFESLGIELVDPWIERP

Download         Length: 429 bp

>T226625 NZ_CP122581:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9960.34 Da        Isoelectric Point: 10.0842

>AT226625 WP_017991284.1 NZ_CP088105:c61665-61399 [Rhizobium ruizarguesonis]
MQPSRPEDKSWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLRGADLDLERQR
DEPRDLQL

Download         Length: 267 bp

>AT226625 NZ_CP122581:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4Q8ZX68

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4R0AD13

References