Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_26
Location 275398..276000 Replicon chromosome
Accession NZ_CP088104
Organism Rhizobium ruizarguesonis strain TA1

Toxin (Protein)


Gene name relE Uniprot ID A0A4Q8ZZ56
Locus tag RlegTA1_RS01410 Protein ID WP_018072489.1
Coordinates 275398..275643 (+) Length 82 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4Q8ZYY9
Locus tag RlegTA1_RS01415 Protein ID WP_018072490.1
Coordinates 275653..276000 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegTA1_RS01370 (RlegTA1_01370) 270821..271252 + 432 WP_012755989.1 DUF2948 family protein -
RlegTA1_RS01375 (RlegTA1_01375) 271369..272667 + 1299 WP_027689562.1 histidinol dehydrogenase -
RlegTA1_RS01380 (RlegTA1_01380) 272672..273145 + 474 WP_018072486.1 UPF0262 family protein -
RlegTA1_RS01385 (RlegTA1_01385) 273142..273627 + 486 WP_017992883.1 low molecular weight phosphatase family protein -
RlegTA1_RS01390 (RlegTA1_01390) 273751..273969 + 219 WP_003545338.1 translation initiation factor IF-1 -
RlegTA1_RS01395 (RlegTA1_01395) 274027..274647 + 621 WP_003545339.1 Maf-like protein -
RlegTA1_RS01400 (RlegTA1_01400) 274781..274993 + 213 WP_017990235.1 DNA gyrase inhibitor YacG -
RlegTA1_RS01410 (RlegTA1_01410) 275398..275643 + 246 WP_018072489.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
RlegTA1_RS01415 (RlegTA1_01415) 275653..276000 + 348 WP_018072490.1 helix-turn-helix transcriptional regulator Antitoxin
RlegTA1_RS01420 (RlegTA1_01420) 276301..276564 - 264 Protein_278 transposase -
RlegTA1_RS01425 (RlegTA1_01425) 276572..278017 - 1446 WP_027689563.1 HlyD family type I secretion periplasmic adaptor subunit -
RlegTA1_RS01430 (RlegTA1_01430) 278032..279747 - 1716 WP_027689564.1 type I secretion system permease/ATPase -
RlegTA1_RS01435 (RlegTA1_01435) 279838..280413 - 576 WP_018072494.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(60-114)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 8978.54 Da        Isoelectric Point: 10.6821

>T226624 WP_018072489.1 NZ_CP088104:275398-275643 [Rhizobium ruizarguesonis]
MKKIAYSKAAAKALRKMQPKRAAAIVAKVEAFANGETVDLKKLQGSDFFRIRVGQDRVVIDDQTMQVLVIKAGPRGDIYN
E

Download         Length: 246 bp

>T226624 NZ_CP122579:c139248-138805 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12533.12 Da        Isoelectric Point: 4.3851

>AT226624 WP_018072490.1 NZ_CP088104:275653-276000 [Rhizobium ruizarguesonis]
MGEIQKLTIDGKGYVLLSEDDYQDLVDVSDARAAKARIDAGEETWPEDVVKALIAGEDPVRVFRKHRGMSIKELAKKSGL
SQPYLSEIETGKKEGSLDALRSIASALDVDLDDVA

Download         Length: 348 bp

>AT226624 NZ_CP122579:c139475-139245 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q8ZZ56

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q8ZYY9

References