Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2143317..2143888 Replicon chromosome
Accession NZ_CP088100
Organism Bradyrhizobium japonicum strain CC829

Toxin (Protein)


Gene name mazF Uniprot ID A0A1L3FM63
Locus tag BjapCC829_RS09900 Protein ID WP_063985200.1
Coordinates 2143317..2143670 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A8T5V1Z1
Locus tag BjapCC829_RS09905 Protein ID WP_063985199.1
Coordinates 2143667..2143888 (-) Length 74 a.a.

Genomic Context

BjapCC829_RS09880BjapCC829_RS09885BjapCC829_RS09895BjapCC829_RS09910BjapCC829_RS09915BjapCC829_RS09890BjapCC829_RS09900BjapCC829_RS09905
Location: 2139608..2139853 (246 bp)
Type: Others
Protein ID: WP_063985204.1
Location: 2140087..2141250 (1164 bp)
Type: Others
Protein ID: WP_063985203.1
Location: 2141884..2143215 (1332 bp)
Type: Others
Protein ID: WP_063985201.1
Location: 2144068..2145174 (1107 bp)
Type: Others
Protein ID: WP_028148596.1
Location: 2145351..2148488 (3138 bp)
Type: Others
Protein ID: WP_063985198.1
Location: 2141375..2141803 (429 bp)
Type: Others
Protein ID: WP_063985202.1
Location: 2143317..2143670 (354 bp)
Type: Toxin
Protein ID: WP_063985200.1
Location: 2143667..2143888 (222 bp)
Type: Antitoxin
Protein ID: WP_063985199.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BjapCC829_RS09880 (BjapCC829_09880)2139608..2139853+246WP_063985204.1hypothetical protein-
BjapCC829_RS09885 (BjapCC829_09885)2140087..2141250+1164WP_063985203.1crosslink repair DNA glycosylase YcaQ family protein-
BjapCC829_RS09890 (BjapCC829_09890)2141375..2141803-429WP_063985202.1DUF2809 domain-containing protein-
BjapCC829_RS09895 (BjapCC829_09895)2141884..2143215+1332WP_063985201.1MFS transporter-
BjapCC829_RS09900 (BjapCC829_09900)2143317..2143670-354WP_063985200.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BjapCC829_RS09905 (BjapCC829_09905)2143667..2143888-222WP_063985199.1antitoxin MazE family proteinAntitoxin
BjapCC829_RS09910 (BjapCC829_09910)2144068..2145174+1107WP_028148596.1efflux RND transporter periplasmic adaptor subunit-
BjapCC829_RS09915 (BjapCC829_09915)2145351..2148488+3138WP_063985198.1efflux RND transporter permease subunit-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin

Antitoxin MazE-like

(11-73)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12602.39 Da        Isoelectric Point: 6.3275

>T226620 WP_063985200.1 NZ_CP088100:c2143670-2143317 [Bradyrhizobium japonicum]
MKRGEVWTVAGGKDYAGKPRPVVIVQDDSFDATNSITVCAFTTDETEAPLFRLKVEPNDGNGLRAPSRLMVDKITTVPKA
KVGTLVGRLDDDDLLRLNRAILVFLGLAGSQRSASAD

Download         Length: 354 bp

>T226620 NZ_CP122578:c4735859-4735575 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8284.21 Da        Isoelectric Point: 7.3202

>AT226620 WP_063985199.1 NZ_CP088100:c2143888-2143667 [Bradyrhizobium japonicum]
MSPSKPKPSRMKVQAHRDRLRAQGLRPIQIWVPDIRSPSFQSEAHRQSLAVATSSHESEDQGFIDAVSDWTDE

Download         Length: 222 bp

>AT226620 NZ_CP122578:c4736091-4735849 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1L3FM63

Antitoxin

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Source
ID
Structure
No matching records found

References