Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-Phd |
| Location | 57485..58176 | Replicon | plasmid pSU303_1 |
| Accession | NZ_CP088096 | ||
| Organism | Rhizobium leguminosarum bv. viciae strain SU303 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | RlegSU303_RS24850 | Protein ID | WP_131627370.1 |
| Coordinates | 57485..57913 (-) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | RlegSU303_RS24855 | Protein ID | WP_131627368.1 |
| Coordinates | 57910..58176 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RlegSU303_RS24815 (RlegSU303_24815) | 52716..52868 | - | 153 | Protein_52 | EF-hand domain-containing protein | - |
| RlegSU303_RS24820 (RlegSU303_24820) | 53035..53682 | + | 648 | WP_131627374.1 | TetR/AcrR family transcriptional regulator | - |
| RlegSU303_RS24825 (RlegSU303_24825) | 54003..54218 | + | 216 | Protein_54 | PAS domain S-box protein | - |
| RlegSU303_RS24830 (RlegSU303_24830) | 54382..55221 | + | 840 | WP_029871147.1 | transporter substrate-binding domain-containing protein | - |
| RlegSU303_RS24835 (RlegSU303_24835) | 55335..55997 | + | 663 | WP_131627372.1 | amino acid ABC transporter permease | - |
| RlegSU303_RS24840 (RlegSU303_24840) | 56002..56661 | + | 660 | WP_024319797.1 | amino acid ABC transporter permease | - |
| RlegSU303_RS24845 (RlegSU303_24845) | 56674..57444 | + | 771 | WP_017956575.1 | amino acid ABC transporter ATP-binding protein | - |
| RlegSU303_RS24850 (RlegSU303_24850) | 57485..57913 | - | 429 | WP_131627370.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| RlegSU303_RS24855 (RlegSU303_24855) | 57910..58176 | - | 267 | WP_131627368.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| RlegSU303_RS24860 (RlegSU303_24860) | 58428..59189 | + | 762 | WP_131627366.1 | GntR family transcriptional regulator | - |
| RlegSU303_RS24865 (RlegSU303_24865) | 59183..59968 | + | 786 | WP_094088146.1 | transporter substrate-binding domain-containing protein | - |
| RlegSU303_RS24870 (RlegSU303_24870) | 60048..60719 | + | 672 | WP_131627364.1 | amino acid ABC transporter permease | - |
| RlegSU303_RS24875 (RlegSU303_24875) | 60716..61375 | + | 660 | WP_017956570.1 | amino acid ABC transporter permease | - |
| RlegSU303_RS24880 (RlegSU303_24880) | 61353..62078 | + | 726 | WP_017956569.1 | amino acid ABC transporter ATP-binding protein | - |
| RlegSU303_RS24885 (RlegSU303_24885) | 62239..62610 | - | 372 | WP_017956568.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| RlegSU303_RS24890 (RlegSU303_24890) | 62610..62867 | - | 258 | WP_003550229.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..938151 | 938151 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15891.19 Da Isoelectric Point: 4.7981
>T226615 WP_131627370.1 NZ_CP088096:c57913-57485 [Rhizobium leguminosarum bv. viciae]
VRLLLDTNVLSEVTRPRPDARVLQWLDSLDEDRSFISTVSIAEIRRGVALMESGRKRDALAEWLAQDLPQRFEQRVTPVD
QPVAIVWGDLMGLAKRSGRGLSSMDGLIAATAIAHDLTLATRNIKDFEGFGIELVDPWIERP
VRLLLDTNVLSEVTRPRPDARVLQWLDSLDEDRSFISTVSIAEIRRGVALMESGRKRDALAEWLAQDLPQRFEQRVTPVD
QPVAIVWGDLMGLAKRSGRGLSSMDGLIAATAIAHDLTLATRNIKDFEGFGIELVDPWIERP
Download Length: 429 bp
>T226615 NZ_CP122578:c1800068-1799652 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9846.19 Da Isoelectric Point: 10.0862
>AT226615 WP_131627368.1 NZ_CP088096:c58176-57910 [Rhizobium leguminosarum bv. viciae]
MQPSRPEDKNWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLSGADLDLGRQR
DEPRDLQL
MQPSRPEDKNWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLSGADLDLGRQR
DEPRDLQL
Download Length: 267 bp
>AT226615 NZ_CP122578:c1800295-1800065 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|