Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 57485..58176 Replicon plasmid pSU303_1
Accession NZ_CP088096
Organism Rhizobium leguminosarum bv. viciae strain SU303

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegSU303_RS24850 Protein ID WP_131627370.1
Coordinates 57485..57913 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RlegSU303_RS24855 Protein ID WP_131627368.1
Coordinates 57910..58176 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegSU303_RS24815 (RlegSU303_24815) 52716..52868 - 153 Protein_52 EF-hand domain-containing protein -
RlegSU303_RS24820 (RlegSU303_24820) 53035..53682 + 648 WP_131627374.1 TetR/AcrR family transcriptional regulator -
RlegSU303_RS24825 (RlegSU303_24825) 54003..54218 + 216 Protein_54 PAS domain S-box protein -
RlegSU303_RS24830 (RlegSU303_24830) 54382..55221 + 840 WP_029871147.1 transporter substrate-binding domain-containing protein -
RlegSU303_RS24835 (RlegSU303_24835) 55335..55997 + 663 WP_131627372.1 amino acid ABC transporter permease -
RlegSU303_RS24840 (RlegSU303_24840) 56002..56661 + 660 WP_024319797.1 amino acid ABC transporter permease -
RlegSU303_RS24845 (RlegSU303_24845) 56674..57444 + 771 WP_017956575.1 amino acid ABC transporter ATP-binding protein -
RlegSU303_RS24850 (RlegSU303_24850) 57485..57913 - 429 WP_131627370.1 type II toxin-antitoxin system VapC family toxin Toxin
RlegSU303_RS24855 (RlegSU303_24855) 57910..58176 - 267 WP_131627368.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RlegSU303_RS24860 (RlegSU303_24860) 58428..59189 + 762 WP_131627366.1 GntR family transcriptional regulator -
RlegSU303_RS24865 (RlegSU303_24865) 59183..59968 + 786 WP_094088146.1 transporter substrate-binding domain-containing protein -
RlegSU303_RS24870 (RlegSU303_24870) 60048..60719 + 672 WP_131627364.1 amino acid ABC transporter permease -
RlegSU303_RS24875 (RlegSU303_24875) 60716..61375 + 660 WP_017956570.1 amino acid ABC transporter permease -
RlegSU303_RS24880 (RlegSU303_24880) 61353..62078 + 726 WP_017956569.1 amino acid ABC transporter ATP-binding protein -
RlegSU303_RS24885 (RlegSU303_24885) 62239..62610 - 372 WP_017956568.1 type II toxin-antitoxin system RelE/ParE family toxin -
RlegSU303_RS24890 (RlegSU303_24890) 62610..62867 - 258 WP_003550229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..938151 938151


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-69)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15891.19 Da        Isoelectric Point: 4.7981

>T226615 WP_131627370.1 NZ_CP088096:c57913-57485 [Rhizobium leguminosarum bv. viciae]
VRLLLDTNVLSEVTRPRPDARVLQWLDSLDEDRSFISTVSIAEIRRGVALMESGRKRDALAEWLAQDLPQRFEQRVTPVD
QPVAIVWGDLMGLAKRSGRGLSSMDGLIAATAIAHDLTLATRNIKDFEGFGIELVDPWIERP

Download         Length: 429 bp

>T226615 NZ_CP122578:c1800068-1799652 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGGGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCACCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTACCGGGCCTGGTGCTGG
AAGACTGGGTAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9846.19 Da        Isoelectric Point: 10.0862

>AT226615 WP_131627368.1 NZ_CP088096:c58176-57910 [Rhizobium leguminosarum bv. viciae]
MQPSRPEDKNWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLSGADLDLGRQR
DEPRDLQL

Download         Length: 267 bp

>AT226615 NZ_CP122578:c1800295-1800065 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGTGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References