Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 62965..63656 Replicon plasmid pWSM1455_1
Accession NZ_CP088091
Organism Rhizobium laguerreae strain WSM1455

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegWSM1455_RS24245 Protein ID WP_131641204.1
Coordinates 62965..63393 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RlegWSM1455_RS24250 Protein ID WP_077977017.1
Coordinates 63390..63656 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegWSM1455_RS24210 (RlegWSM1455_24210) 58175..58421 + 247 Protein_57 plasmid stabilization protein -
RlegWSM1455_RS24215 (RlegWSM1455_24215) 58771..59418 + 648 WP_131641206.1 TetR/AcrR family transcriptional regulator -
RlegWSM1455_RS24220 (RlegWSM1455_24220) 59443..59549 + 107 Protein_59 methyl-accepting chemotaxis protein -
RlegWSM1455_RS34290 59633..59761 - 129 WP_260685470.1 hypothetical protein -
RlegWSM1455_RS24225 (RlegWSM1455_24225) 59862..60701 + 840 WP_017956578.1 transporter substrate-binding domain-containing protein -
RlegWSM1455_RS24230 (RlegWSM1455_24230) 60815..61477 + 663 WP_131641205.1 amino acid ABC transporter permease -
RlegWSM1455_RS24235 (RlegWSM1455_24235) 61482..62141 + 660 WP_077977015.1 amino acid ABC transporter permease -
RlegWSM1455_RS24240 (RlegWSM1455_24240) 62154..62924 + 771 WP_062943009.1 amino acid ABC transporter ATP-binding protein -
RlegWSM1455_RS24245 (RlegWSM1455_24245) 62965..63393 - 429 WP_131641204.1 type II toxin-antitoxin system VapC family toxin Toxin
RlegWSM1455_RS24250 (RlegWSM1455_24250) 63390..63656 - 267 WP_077977017.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
RlegWSM1455_RS24255 (RlegWSM1455_24255) 63911..64660 + 750 WP_077977018.1 GntR family transcriptional regulator -
RlegWSM1455_RS24260 (RlegWSM1455_24260) 64664..65449 + 786 WP_077977019.1 transporter substrate-binding domain-containing protein -
RlegWSM1455_RS24265 (RlegWSM1455_24265) 65529..66200 + 672 WP_077977020.1 amino acid ABC transporter permease -
RlegWSM1455_RS24270 (RlegWSM1455_24270) 66197..66856 + 660 WP_027664862.1 amino acid ABC transporter permease -
RlegWSM1455_RS24275 (RlegWSM1455_24275) 66834..67559 + 726 WP_012755581.1 amino acid ABC transporter ATP-binding protein -
RlegWSM1455_RS24280 (RlegWSM1455_24280) 67823..68194 - 372 WP_168258582.1 type II toxin-antitoxin system RelE/ParE family toxin -
RlegWSM1455_RS24285 (RlegWSM1455_24285) 68194..68451 - 258 WP_131641202.1 CopG family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - htpB 1..1064136 1064136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-67)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15850.14 Da        Isoelectric Point: 4.9652

>T226606 WP_131641204.1 NZ_CP088091:c63393-62965 [Rhizobium laguerreae]
VRLLLDTNVLSQVTRPRPDARVLQWLDSLDEDRSFISIVSIAEIRRGVALMESGRKRDALAEWLAQDLPQRFEQRVIPVD
QPVAIAWGDVMGLAKRSGRGLSSMDGLIAATAIAHDLTLATRNIKDFEGFGIELVDPWTERS

Download         Length: 429 bp

>T226606 NZ_CP122573:c4886901-4885984 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9946.31 Da        Isoelectric Point: 10.0842

>AT226606 WP_077977017.1 NZ_CP088091:c63656-63390 [Rhizobium laguerreae]
MQPSRPEDKSWTVASAKAKLSEVIERAQATPQTIMRNGKPSVVVVSAEEWQRKTARKGTLAEFLMQSPLRGADLDVERQR
DEPRDLQL

Download         Length: 267 bp

>AT226606 NZ_CP122573:c4887665-4886907 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGTCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References