Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2781124..2781797 Replicon chromosome
Accession NZ_CP088090
Organism Rhizobium laguerreae strain WSM1455

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegWSM1455_RS14195 Protein ID WP_132610168.1
Coordinates 2781124..2781537 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RlegWSM1455_RS14200 Protein ID WP_077978770.1
Coordinates 2781534..2781797 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegWSM1455_RS14185 (RlegWSM1455_14185) 2778546..2779754 - 1209 WP_131639474.1 efflux RND transporter periplasmic adaptor subunit -
RlegWSM1455_RS14190 (RlegWSM1455_14190) 2780023..2780943 - 921 WP_077978768.1 adenylate/guanylate cyclase domain-containing protein -
RlegWSM1455_RS14195 (RlegWSM1455_14195) 2781124..2781537 - 414 WP_132610168.1 type II toxin-antitoxin system VapC family toxin Toxin
RlegWSM1455_RS14200 (RlegWSM1455_14200) 2781534..2781797 - 264 WP_077978770.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
RlegWSM1455_RS14205 (RlegWSM1455_14205) 2781886..2783436 - 1551 WP_131639476.1 SpoVR family protein -
RlegWSM1455_RS14210 (RlegWSM1455_14210) 2783433..2784707 - 1275 WP_077978772.1 YeaH/YhbH family protein -
RlegWSM1455_RS14215 (RlegWSM1455_14215) 2784720..2786663 - 1944 WP_027664285.1 PrkA family serine protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(9-54)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15185.57 Da        Isoelectric Point: 5.2217

>T226605 WP_132610168.1 NZ_CP088090:c2781537-2781124 [Rhizobium laguerreae]
MTAWMLDTNMVSHVIKGDRPEIIERLAALPMEDIVISSITEGELFYGLAKRGYPKALSERIRQFLLRVDVLPWDHDVTRT
YGDLRAACEAKGVTLAPLDMMIAAHAIATAATLVTRDKAFARVSEPLKVDDWASEGS

Download         Length: 414 bp

>T226605 NZ_CP122573:c4730084-4729800 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10130.22 Da        Isoelectric Point: 4.7051

>AT226605 WP_077978770.1 NZ_CP088090:c2781797-2781534 [Rhizobium laguerreae]
MATRTAKIFTTGRSQAVRLPAEFRFEESEVFVRRDPKTGDVILSRKPESWDGLFELYGKDQVPDDFLGPDDRQQPSHDRD
PFEGWKE

Download         Length: 264 bp

>AT226605 NZ_CP122573:c4730316-4730074 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References