Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 710669..712158 Replicon chromosome
Accession NZ_CP088090
Organism Rhizobium laguerreae strain WSM1455

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag RlegWSM1455_RS03485 Protein ID WP_168260312.1
Coordinates 710669..711931 (-) Length 421 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag RlegWSM1455_RS03490 Protein ID WP_231285147.1
Coordinates 711928..712158 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegWSM1455_RS03445 (RlegWSM1455_03445) 705772..706221 - 450 WP_168259776.1 DCC1-like thiol-disulfide oxidoreductase family protein -
RlegWSM1455_RS03450 (RlegWSM1455_03450) 706245..707153 - 909 WP_168259770.1 MBL fold metallo-hydrolase -
RlegWSM1455_RS03460 (RlegWSM1455_03460) 707546..708184 + 639 WP_206118406.1 nucleotidyltransferase domain-containing protein -
RlegWSM1455_RS03465 (RlegWSM1455_03465) 708195..708614 + 420 WP_231285146.1 hypothetical protein -
RlegWSM1455_RS03475 (RlegWSM1455_03475) 708857..709108 + 252 WP_170268300.1 hypothetical protein -
RlegWSM1455_RS03480 (RlegWSM1455_03480) 709411..710178 - 768 WP_168259773.1 SDR family NAD(P)-dependent oxidoreductase -
RlegWSM1455_RS03485 (RlegWSM1455_03485) 710669..711931 - 1263 WP_168260312.1 type II toxin-antitoxin system HipA family toxin Toxin
RlegWSM1455_RS03490 (RlegWSM1455_03490) 711928..712158 - 231 WP_231285147.1 helix-turn-helix transcriptional regulator Antitoxin
RlegWSM1455_RS03495 (RlegWSM1455_03495) 712423..713031 - 609 WP_221970701.1 TetR/AcrR family transcriptional regulator -
RlegWSM1455_RS03500 (RlegWSM1455_03500) 713143..713829 + 687 WP_222021982.1 PspA/IM30 family protein -
RlegWSM1455_RS03505 (RlegWSM1455_03505) 713880..714161 + 282 WP_003546080.1 YiaA/YiaB family inner membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 421 a.a.        Molecular weight: 45474.32 Da        Isoelectric Point: 6.0168

>T226604 WP_168260312.1 NZ_CP088090:c711931-710669 [Rhizobium laguerreae]
MTSRLLNVWWDGRIVGQFTQDRHGDIGFVYARAWLDDDKTLPLSASLPKRPERFTRRECRPFFGGLLPEESQRLAAARAL
GVSPANDFALLDHLGGDVAGALQLLAEGEAPAETGPIADRQPAPLDEAGIVAVLEALPVRPLLAGEEGLRLSLAGAQSKL
PVVLVDGRIGLPLPGQATTHILKPPIARFKATTENEAFVMRLAAAIGLDVAAVEPRYVQGRPFLLVERYDRVRGAGGLVH
RIHQEDLCQALSVPPETKYASEGGPTFKDCFDLIRRISARPAVDVLKLLDAAIFNLIAGNTDAHGKNFSILYDSQGPRLA
KLYDLLSTVIYPELSPKLAMRIGKRATLTEMDAEGWKVFAGEAGIGTPLVRRRVNELCDKVLTLTGKVADELADVSPDRD
PIDAIAGVITDRAETARLTL

Download         Length: 1263 bp

>T226604 NZ_CP122573:c4628240-4627707 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8177.48 Da        Isoelectric Point: 9.3464

>AT226604 WP_231285147.1 NZ_CP088090:c712158-711928 [Rhizobium laguerreae]
MAKHIQSPTDIGALVRSTRKEQNLRQDELAGVAGVGLRFIVDLEAGKPTAQIGKVLQVLQTLGCSLDILAPGERRQ

Download         Length: 231 bp

>AT226604 NZ_CP122573:c4628517-4628251 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References