Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 493504..494222 Replicon chromosome
Accession NZ_CP088090
Organism Rhizobium laguerreae strain WSM1455

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag RlegWSM1455_RS02425 Protein ID WP_222006178.1
Coordinates 493504..493962 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag RlegWSM1455_RS02430 Protein ID WP_131666250.1
Coordinates 493959..494222 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RlegWSM1455_RS02400 (RlegWSM1455_02400) 489776..490072 - 297 WP_003545797.1 co-chaperone GroES -
RlegWSM1455_RS02405 (RlegWSM1455_02405) 490460..491308 + 849 WP_132613351.1 TIGR01459 family HAD-type hydrolase -
RlegWSM1455_RS02410 (RlegWSM1455_02410) 491340..492332 + 993 WP_077976704.1 bifunctional riboflavin kinase/FAD synthetase -
RlegWSM1455_RS02415 (RlegWSM1455_02415) 492321..492755 - 435 WP_168345901.1 RES family NAD+ phosphorylase -
RlegWSM1455_RS02420 (RlegWSM1455_02420) 492882..493292 - 411 WP_077976703.1 DUF2384 domain-containing protein -
RlegWSM1455_RS02425 (RlegWSM1455_02425) 493504..493962 - 459 WP_222006178.1 type II toxin-antitoxin system VapC family toxin Toxin
RlegWSM1455_RS02430 (RlegWSM1455_02430) 493959..494222 - 264 WP_131666250.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
RlegWSM1455_RS02435 (RlegWSM1455_02435) 494575..497466 + 2892 WP_231285124.1 isoleucine--tRNA ligase -
RlegWSM1455_RS02440 (RlegWSM1455_02440) 497600..498229 + 630 WP_131642854.1 hypothetical protein -
RlegWSM1455_RS02445 (RlegWSM1455_02445) 498282..498719 - 438 WP_032995618.1 nucleoside deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(7-56)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16969.22 Da        Isoelectric Point: 8.4458

>T226603 WP_222006178.1 NZ_CP088090:c493962-493504 [Rhizobium laguerreae]
VIGWLLDTNVIAALINPNGAPSVKSWAAAQDEKKMFISILTLAEYDKGIENLPEDDQNRYRYAASRDALEERFSQRVLSL
SDAAVRHWGVISGRVKLKTGHAPSVVDTLLAATAIEHNLYLVTRNVRDTRFSGAAIFDPWTNYPGQFPLSRR

Download         Length: 459 bp

>T226603 NZ_CP122573:4015419-4015637 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9973.40 Da        Isoelectric Point: 7.0188

>AT226603 WP_131666250.1 NZ_CP088090:c494222-493959 [Rhizobium laguerreae]
MKKITKQSWKLEDAKARFSEVVRRAHSEGPQRVTVRGRDSVVVISAEELDQLTKVEPKKPFVAFMESLDLKGLELEREAD
YGRDAEL

Download         Length: 264 bp

>AT226603 NZ_CP122573:4015018-4015392 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References