Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 7896482..7898012 Replicon chromosome
Accession NZ_CP088088
Organism Bradyrhizobium diazoefficiens strain CB1809

Toxin (Protein)


Gene name rlegT Uniprot ID A0A562QN92
Locus tag BdzoCB1809_RS37165 Protein ID WP_018647871.1
Coordinates 7897092..7898012 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A810CIT3
Locus tag BdzoCB1809_RS37160 Protein ID WP_026312796.1
Coordinates 7896482..7897102 (+) Length 207 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BdzoCB1809_RS37145 (BdzoCB1809_37145) 7892847..7893074 + 228 WP_131234255.1 hypothetical protein -
BdzoCB1809_RS37150 (BdzoCB1809_37150) 7893067..7895547 + 2481 WP_231166584.1 AAA family ATPase -
BdzoCB1809_RS37155 (BdzoCB1809_37155) 7895522..7896268 + 747 WP_018647872.1 DCL family protein -
BdzoCB1809_RS37160 (BdzoCB1809_37160) 7896482..7897102 + 621 WP_026312796.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
BdzoCB1809_RS37165 (BdzoCB1809_37165) 7897092..7898012 + 921 WP_018647871.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
BdzoCB1809_RS37170 (BdzoCB1809_37170) 7898090..7899394 + 1305 WP_028176022.1 SIR2 family protein -
BdzoCB1809_RS37175 (BdzoCB1809_37175) 7899402..7901510 + 2109 WP_011084726.1 DUF87 domain-containing protein -
BdzoCB1809_RS37180 (BdzoCB1809_37180) 7901519..7902040 + 522 WP_011084725.1 exonuclease subunit SbcD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-264)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(12-56)


Sequences

Toxin        


Download         Length: 307 a.a.        Molecular weight: 34027.14 Da        Isoelectric Point: 5.2727

>T226601 WP_018647871.1 NZ_CP088088:7897092-7898012 [Bradyrhizobium diazoefficiens]
MAREPRNIGASVRARLLDRARAERSDFQILLTRYALERLLYRLSASPHRDRFILKGAMLFVTWIADPFRPTRDLDLLGHG
DRDTEAIAETFRAICAQPVVDDGVTFDVAALMATPIREELEYGGVRVRTTATIAGARIPIQVDIGFGDAITPAAVEIDYP
TLLDAPTPHLRAYPVETVVAEKFAALVTLGVANSRLKDFYDLWVISRTFELRRAALAEAIQRTFERRGTVLPSVVPVGLT
DEFAETWAAQWRAFLERDRMAAAPDAFAVTVADLRLFLMPLVVGLKEERIWPPSGPWSPGAAIDEA

Download         Length: 921 bp

>T226601 NZ_CP122573:1985223-1985325 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 207 a.a.        Molecular weight: 23385.28 Da        Isoelectric Point: 10.0691

>AT226601 WP_026312796.1 NZ_CP088088:7896482-7897102 [Bradyrhizobium diazoefficiens]
MPSTSAQRLRALDLLKTRGMLRLKDFIAEGIGPETLARLVREEAVVRPARGLYQLPDAHLEAAHTLAEAAVLVPKGVVCL
TSALQYHELTLQMPSAVWMAIDRSAWRPKIDYPPIRFVRFTGSALTEGIERHRIENVDVPITDPARTIVDCFRYRTKIGL
DVAMEGLREGLRRRRCKPDQLWHYARKARVWSVMRPYVEAMVSDGA

Download         Length: 621 bp

>AT226601 NZ_CP122573:c1985332-1985187 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A562QN92

Antitoxin

Source ID Structure
AlphaFold DB A0A810CIT3

References