Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2484662..2485368 Replicon chromosome
Accession NZ_CP088088
Organism Bradyrhizobium diazoefficiens strain CB1809

Toxin (Protein)


Gene name vapC Uniprot ID A0A837CG53
Locus tag BdzoCB1809_RS11755 Protein ID WP_028175059.1
Coordinates 2484662..2485087 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A837CFL2
Locus tag BdzoCB1809_RS11760 Protein ID WP_028175058.1
Coordinates 2485084..2485368 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BdzoCB1809_RS11725 (BdzoCB1809_11725) 2480667..2481419 + 753 WP_231166655.1 fatty acid desaturase family protein -
BdzoCB1809_RS11730 (BdzoCB1809_11730) 2481499..2481930 + 432 WP_028175063.1 acyl-CoA thioesterase -
BdzoCB1809_RS11735 (BdzoCB1809_11735) 2482122..2482313 + 192 WP_028175062.1 hypothetical protein -
BdzoCB1809_RS11740 (BdzoCB1809_11740) 2482413..2482880 - 468 WP_011085218.1 nuclear transport factor 2 family protein -
BdzoCB1809_RS11745 (BdzoCB1809_11745) 2483036..2483722 + 687 WP_028175061.1 HAD-IA family hydrolase -
BdzoCB1809_RS11750 (BdzoCB1809_11750) 2483814..2484659 + 846 WP_028175060.1 DeoR/GlpR family DNA-binding transcription regulator -
BdzoCB1809_RS11755 (BdzoCB1809_11755) 2484662..2485087 - 426 WP_028175059.1 type II toxin-antitoxin system VapC family toxin Toxin
BdzoCB1809_RS11760 (BdzoCB1809_11760) 2485084..2485368 - 285 WP_028175058.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BdzoCB1809_RS11765 (BdzoCB1809_11765) 2485600..2487150 + 1551 WP_028175057.1 glycerol-3-phosphate dehydrogenase -
BdzoCB1809_RS11770 (BdzoCB1809_11770) 2487147..2488223 + 1077 WP_028175056.1 ABC transporter ATP-binding protein -
BdzoCB1809_RS11775 (BdzoCB1809_11775) 2488236..2489321 + 1086 WP_011085225.1 ABC transporter ATP-binding protein -
BdzoCB1809_RS11780 (BdzoCB1809_11780) 2489321..2490295 + 975 WP_011085226.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(15-77)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15514.68 Da        Isoelectric Point: 4.4561

>T226600 WP_028175059.1 NZ_CP088088:c2485087-2484662 [Bradyrhizobium diazoefficiens]
VNLLLDTNILSEVQRPAPSPNVLAWLDTIDEDRAFISVASIAELRRGIALLEDGRRRSALAAWLADDLPTRFGERVLPID
QAVVERWGDLMAQSRRSGVALSVMDGFFAATALANDLTLATRNVKDFAAFGVPLLNPWDDR

Download         Length: 426 bp

>T226600 NZ_CP122573:870571-870981 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10223.50 Da        Isoelectric Point: 6.7247

>AT226600 WP_028175058.1 NZ_CP088088:c2485368-2485084 [Bradyrhizobium diazoefficiens]
MADHNTAPDTLPADDTWTLANAKARLSQVIDRAQTGPQIITRHGKPNAVVVSAEEWARKTARKGTLAEFLLASPLRGADL
ALDRTHDAPRDEMP

Download         Length: 285 bp

>AT226600 NZ_CP122573:870324-870590 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837CG53

Antitoxin

Source ID Structure
AlphaFold DB A0A837CFL2

References