Detailed information of TA system TA226594

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 83756..84870
• Replicon: plasmid unnamed1
• Accession: NZ_CP088082
• Organism: Ideonella dechloratans strain CCUG 30977

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LRM40_RS18270
• Protein ID: WP_151124312.1
• Coordinates: 84166..84870 (+)
• Length: 235 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LRM40_RS18265
• Protein ID: WP_151124311.1
• Coordinates: 83756..84142 (+)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM40_RS18250 (LRM40_18250)	78905..81109	+	2205	WP_151125277.1	1,4-alpha-glucan branching protein GlgB	-
LRM40_RS18255 (LRM40_18255)	81156..82730	+	1575	WP_151125278.1	4-alpha-glucanotransferase	-
LRM40_RS18260 (LRM40_18260)	82779..83675	+	897	WP_231067897.1	SHOCT domain-containing protein	-
LRM40_RS18265 (LRM40_18265)	83756..84142	+	387	WP_151124311.1	DUF2384 domain-containing protein	Antitoxin
LRM40_RS18270 (LRM40_18270)	84166..84870	+	705	WP_151124312.1	RES family NAD+ phosphorylase	Toxin
LRM40_RS18275 (LRM40_18275)	85335..85475	+	141	WP_022980176.1	hypothetical protein	-
LRM40_RS18280 (LRM40_18280)	85561..86541	-	981	WP_151124314.1	TerC family protein	-
LRM40_RS18285 (LRM40_18285)	86678..87580	+	903	WP_151124315.1	LysR family transcriptional regulator	-
LRM40_RS18290 (LRM40_18290)	87604..88038	-	435	WP_151124316.1	TerB family tellurite resistance protein	-
LRM40_RS18295 (LRM40_18295)	88224..88562	+	339	WP_151124317.1	HPF/RaiA family ribosome-associated protein	-
LRM40_RS18300 (LRM40_18300)	88595..89296	+	702	WP_151124318.1	Bax inhibitor-1/YccA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	ugd	1..708898	708898

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (60-201)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (77-125)

Sequences

Toxin

Protein

• Length: 235 a.a.
• Molecular weight: 26190.53 Da
• Isoelectric Point: 7.0180

>T226594 WP_151124312.1 NZ_CP088082:84166-84870 [Ideonella dechloratans]
MDWQPDWFEGTIRPQATLAWRGVEAQHVVSTMRLVDSAAEQDLLEQLLEGSKPALPPAARPLHYLLATPFRYRPPHASRF
RAPHSPGQWYGAQTLYAACAEVAYWRHRFILDSAGLAGRELLTEHTFFQGAIQGLAIDLTQPPWDQAQALWTHDSDYRAP
QAVARSAQIRGVQWLAYASVRAPGHHCAVVFDPASLAEPPGGLDATQQTWHCKATAQRVMFARGAERFEWAWTG

Nucleotide

• Length: 705 bp

>T226594 NZ_CP122569:c14266-13916 [Klebsiella pneumoniae]
ATGTGGGTCATCGAGACAACCGACACCTTTGATGAGTGGTTCGATGCTCTGGATGATACCGATAGAGCAAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGCCCCATGCTGTCGAGGCCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTTCGGGTCCAAAGCAAAGGAGATCCTATCAGAGCGTTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGTGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 13469.66 Da
• Isoelectric Point: 9.9122

>AT226594 WP_151124311.1 NZ_CP088082:83756-84142 [Ideonella dechloratans]
MSPATAALAISAPDAATVLAKATVRASELLGLKGVTLARTLGLSEPTVSRLLKGQKGLAPDTKEGELALLLVRVYRSLDA
LVGTDDQKRRAWMNSYNQALGGEPLQLIQKAEGLVATLNYLDAMRAPA

Nucleotide

• Length: 387 bp

>AT226594 NZ_CP122569:c13911-13609 [Klebsiella pneumoniae]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA