Detailed information of TA system TA226593

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2563986..2564776
• Replicon: chromosome
• Accession: NZ_CP088081
• Organism: Ideonella dechloratans strain CCUG 30977

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: LRM40_RS11965
• Protein ID: WP_151123362.1
• Coordinates: 2563986..2564486 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: LRM40_RS11970
• Protein ID: WP_150094976.1
• Coordinates: 2564483..2564776 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM40_RS11930 (LRM40_11935)	2559597..2559854	+	258	WP_151123368.1	hypothetical protein	-
LRM40_RS11935 (LRM40_11940)	2559878..2560822	+	945	WP_231067521.1	hypothetical protein	-
LRM40_RS11940 (LRM40_11945)	2560983..2561426	+	444	WP_151123367.1	hypothetical protein	-
LRM40_RS11945 (LRM40_11950)	2561487..2561963	+	477	WP_151123366.1	DUF2924 domain-containing protein	-
LRM40_RS11950 (LRM40_11955)	2561960..2563300	+	1341	WP_151123365.1	recombinase family protein	-
LRM40_RS11955 (LRM40_11960)	2563297..2563749	+	453	WP_151123364.1	hypothetical protein	-
LRM40_RS11960 (LRM40_11965)	2563755..2563982	-	228	WP_151123363.1	hypothetical protein	-
LRM40_RS11965 (LRM40_11970)	2563986..2564486	-	501	WP_151123362.1	GNAT family N-acetyltransferase	Toxin
LRM40_RS11970 (LRM40_11975)	2564483..2564776	-	294	WP_150094976.1	DUF1778 domain-containing protein	Antitoxin
LRM40_RS11975	2566367..2566606	+	240	WP_151123360.1	hypothetical protein	-
LRM40_RS11980 (LRM40_11980)	2566745..2567482	-	738	WP_151126053.1	IS21-like element helper ATPase IstB	-
LRM40_RS11985 (LRM40_11985)	2567519..2569063	-	1545	WP_151126052.1	IS21 family transposase	-
LRM40_RS11990 (LRM40_11990)	2569209..2569358	-	150	WP_231067522.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (40-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-96)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18404.29 Da
• Isoelectric Point: 10.0337

>T226593 WP_151123362.1 NZ_CP088081:c2564486-2563986 [Ideonella dechloratans]
VTLRAPEPLAAQHRLEGFDCGKPALNDWLLRHARQAQGSGSAKTFVVAEDDGRVAGYFSLTVGQVDTLEAPERIRKGMGQ
YPLPVVILARLAVSVVDQGRGIGFGLLQDAIRRTMLIAEQAGIRAMLTHPIDEEAARFYTRFGFIASPLREQQLLLLLKD
ARRWVR

Nucleotide

• Length: 501 bp

>T226593 NZ_CP122567:c137920-137507 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10717.21 Da
• Isoelectric Point: 5.8270

>AT226593 WP_150094976.1 NZ_CP088081:c2564776-2564483 [Ideonella dechloratans]
MTAVASSPSARSARLGLRATPEQEVVLRRAAEVAHKSLTDFILDSACLAAEQTLLDQRLFMVSGSQYQALMDLLDRPEQA
NEGLRDLFARKAPWDTK

Nucleotide

• Length: 294 bp

>AT226593 NZ_CP122567:c138147-137917 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA