Detailed information of TA system TA226592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 296134..296749
• Replicon: chromosome
• Accession: NZ_CP088081
• Organism: Ideonella dechloratans strain CCUG 30977

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LRM40_RS01395
• Protein ID: WP_231067666.1
• Coordinates: 296134..296511 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LRM40_RS01400
• Protein ID: WP_151124526.1
• Coordinates: 296498..296749 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM40_RS01370 (LRM40_01375)	292279..293700	-	1422	WP_151124523.1	ATP-binding protein	-
LRM40_RS01375 (LRM40_01380)	293697..294359	-	663	WP_151124524.1	winged helix-turn-helix domain-containing protein	-
LRM40_RS01380 (LRM40_01385)	294383..295129	-	747	WP_231067664.1	cytochrome b/b6 domain-containing protein	-
LRM40_RS01385 (LRM40_01390)	295139..295624	-	486	WP_231067665.1	diheme cytochrome c	-
LRM40_RS01390 (LRM40_01395)	295632..296000	-	369	WP_231067863.1	DUF1924 domain-containing protein	-
LRM40_RS01395 (LRM40_01400)	296134..296511	-	378	WP_231067666.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LRM40_RS01400 (LRM40_01405)	296498..296749	-	252	WP_151124526.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LRM40_RS01405 (LRM40_01410)	296845..297936	-	1092	WP_170288890.1	GGDEF domain-containing protein	-
LRM40_RS01410 (LRM40_01415)	298029..299225	-	1197	WP_151124528.1	amino acid aminotransferase	-
LRM40_RS01415 (LRM40_01420)	299320..301152	+	1833	WP_151124529.1	bifunctional metallophosphatase/5'-nucleotidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	pilT / adeG	126..349322	349196

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-96)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-77)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14053.40 Da
• Isoelectric Point: 10.3314

>T226592 WP_231067666.1 NZ_CP088081:c296511-296134 [Ideonella dechloratans]
MTTSEGVKTTKRKYKYKLRFMPEALEEWHKLDGSVKAPLKKLLEKRLDNPHVPGGELHGPLTGCYKIKLRQQGARLVYAV
EDDHLIVTVVAVDRREDGIVYQSSIARLSAAAAALSQALRDKLKK

Nucleotide

• Length: 378 bp

>T226592 NZ_CP122567:c87458-86988 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
TTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9447.85 Da
• Isoelectric Point: 4.8430

>AT226592 WP_151124526.1 NZ_CP088081:c296749-296498 [Ideonella dechloratans]
MESILADVAVSMSEFKKNPAAVLREANHRPVAVLNHNRAAFYMVEPRLFEAMMEELADQELYRKAASRLVDKSRAIEVDI
DDL

Nucleotide

• Length: 252 bp

>AT226592 NZ_CP122567:c87898-87455 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGATCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGCGAATCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACGTTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACAGGAGCGTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA