226589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 427399..428035 Replicon chromosome
Accession NZ_CP088020
Organism Radiobacillus kanasensis strain 80

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KO561_RS02270 Protein ID WP_231095551.1
Coordinates 427685..428035 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KO561_RS02265 Protein ID WP_231095550.1
Coordinates 427399..427680 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KO561_RS02245 (KO561_02245) 422937..423293 + 357 WP_231095547.1 holo-ACP synthase -
KO561_RS02250 (KO561_02250) 423383..424903 + 1521 WP_231095548.1 NAD(P)H-hydrate dehydratase -
KO561_RS02255 (KO561_02255) 424952..425971 + 1020 WP_231095549.1 outer membrane lipoprotein carrier protein LolA -
KO561_RS02260 (KO561_02260) 426097..427215 + 1119 WP_231097029.1 alanine racemase -
KO561_RS02265 (KO561_02265) 427399..427680 + 282 WP_231095550.1 antitoxin Antitoxin
KO561_RS02270 (KO561_02270) 427685..428035 + 351 WP_231095551.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KO561_RS02275 (KO561_02275) 428428..429297 + 870 WP_269140684.1 RsbT co-antagonist protein RsbRA -
KO561_RS02280 (KO561_02280) 429302..429658 + 357 WP_231095552.1 STAS domain-containing protein -
KO561_RS02285 (KO561_02285) 429661..430068 + 408 WP_231095553.1 anti-sigma regulatory factor -
KO561_RS02290 (KO561_02290) 430120..431112 + 993 WP_231095554.1 PP2C family protein-serine/threonine phosphatase -
KO561_RS02295 (KO561_02295) 431177..431506 + 330 WP_231095555.1 STAS domain-containing protein -
KO561_RS02300 (KO561_02300) 431506..431982 + 477 WP_231095556.1 anti-sigma B factor RsbW -
KO561_RS02305 (KO561_02305) 431954..432745 + 792 WP_231095557.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12991.02 Da        Isoelectric Point: 5.7117

>T226589 WP_231095551.1 NZ_CP088020:427685-428035 [Radiobacillus kanasensis]
MIVKRGEVYFADLSPVVGSEQGGVRPVLVLQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAQKYGFERDSVILLEQI
RTIDKQRLTDKITQLDQHMMENINKALEISLGLTDF

Download         Length: 351 bp

>T226589 NZ_CP122565:29473-29664 [Auritidibacter ignavus]
ATGAAAGAGCTCAGGCCCGGCTCGTCTGGCCGGTCCGAGTTGCGCGTTCTGTTCGCGTTCGATCCAGAGCGAGTGGCGAT
CATGCTGATCGCCGAAGATAAGATCGGCGATTGGAAACGCTGGTATAAGAAGCACATTTCGTTGGCCGACGACCTCTTCG
ACGAGCATCTGGCCCGACTGAGAAGAGAGTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10718.27 Da        Isoelectric Point: 4.9170

>AT226589 WP_231095550.1 NZ_CP088020:427399-427680 [Radiobacillus kanasensis]
MVLSESLQEIVVRLPKNLLNEVDGLMRNENSDLSDFICQATKSYLREKKKRHIRESMQRGYMEMAKINLNIASEAFQAEE
EAETTLERLVSGV

Download         Length: 282 bp

>AT226589 NZ_CP122565:29670-29975 [Auritidibacter ignavus]
ATGCCAAAGAACCTGAAGGATTTCGTCGCCGAGCATCCTGTTGACCGGGGACGGGTTGAGGCGCACAAGAAGCGGATGCT
TGCTGAGGTTCGCGCCTACCGTCTGCGAGAGCTACGGGAGCAGGCCGGACTGACGCAAGCGCAGCTGGCAGAGCGCATTG
GCGTCGGGCAGCGGCAGGTTTCGAAGATCGAGCAAGGCGACCTCGACAGCGCGAAGGTTGGCACCATCCGCAGTTACCTT
GAGGCCGTCGGTGGCGAACTCTCCCTTGAGTACGTGATGGGAGACCAGCGAATGAAGGTCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References