Detailed information of TA system TA226588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4744774..4745309
• Replicon: chromosome
• Accession: NZ_CP088019
• Organism: Pectobacterium carotovorum strain 25.1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LQF52_RS21475
• Protein ID: WP_039533010.1
• Coordinates: 4745022..4745309 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A221TFM4
• Locus tag: LQF52_RS21470
• Protein ID: WP_039533012.1
• Coordinates: 4744774..4745025 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF52_RS21440 (LQF52_21440)	4740196..4740522	+	327	WP_039546304.1	helix-turn-helix domain-containing protein	-
LQF52_RS21445 (LQF52_21445)	4740507..4740821	+	315	WP_039474444.1	HipA N-terminal domain-containing protein	-
LQF52_RS21450 (LQF52_21450)	4740818..4741858	+	1041	WP_039546300.1	HipA domain-containing protein	-
LQF52_RS21455 (LQF52_21455)	4741919..4742542	-	624	WP_039474438.1	LysE family translocator	-
LQF52_RS21460 (LQF52_21460)	4742821..4743576	+	756	WP_039546298.1	thiol:disulfide interchange protein DsbG	-
LQF52_RS21465 (LQF52_21465)	4743611..4744516	-	906	WP_231051788.1	siderophore-interacting protein	-
LQF52_RS21470 (LQF52_21470)	4744774..4745025	+	252	WP_039533012.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LQF52_RS21475 (LQF52_21475)	4745022..4745309	+	288	WP_039533010.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LQF52_RS21480 (LQF52_21480)	4745412..4746764	-	1353	WP_040032226.1	glutathione-disulfide reductase	-
LQF52_RS21485 (LQF52_21485)	4746893..4747735	-	843	WP_039316638.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
LQF52_RS21490 (LQF52_21490)	4747954..4748682	+	729	WP_180776371.1	DUF1266 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11128.20 Da
• Isoelectric Point: 10.2532

>T226588 WP_039533010.1 NZ_CP088019:4745022-4745309 [Pectobacterium carotovorum]
MSYRVKFREDALKEWLKLDKTIQQQFAKKLKECCENPHIPAAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T226588 NZ_CP122565:26963-27388 [Auritidibacter ignavus]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCCGATCAGTACCGCCGACGCGCAGAC
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9131.50 Da
• Isoelectric Point: 4.0637

>AT226588 WP_039533012.1 NZ_CP088019:4744774-4745025 [Pectobacterium carotovorum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELIKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT226588 NZ_CP122565:26733-26966 [Auritidibacter ignavus]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A221TFM4