Detailed information of TA system TA226586

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): sdenTA/AbiEii(toxin)
• Location: 4668493..4669933
• Replicon: chromosome
• Accession: NZ_CP088019
• Organism: Pectobacterium carotovorum strain 25.1

Toxin (Protein)

• Gene name: sdenT
• Uniprot ID: -
• Locus tag: LQF52_RS21125
• Protein ID: WP_039546397.1
• Coordinates: 4668493..4669380 (-)
• Length: 296 a.a.

Antitoxin (Protein)

• Gene name: sdenA
• Uniprot ID: A0A7V8PRU9
• Locus tag: LQF52_RS21130
• Protein ID: WP_039474562.1
• Coordinates: 4669409..4669933 (-)
• Length: 175 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF52_RS21105 (LQF52_21105)	4664492..4665313	+	822	WP_039546460.1	M55 family metallopeptidase	-
LQF52_RS21110 (LQF52_21110)	4665373..4666323	+	951	WP_039546458.1	isoaspartyl peptidase/L-asparaginase	-
LQF52_RS21115 (LQF52_21115)	4666528..4667436	+	909	WP_039474568.1	LysR family transcriptional regulator	-
LQF52_RS21120 (LQF52_21120)	4667535..4668398	+	864	WP_039474565.1	YicC/YloC family endoribonuclease	-
LQF52_RS21125 (LQF52_21125)	4668493..4669380	-	888	WP_039546397.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LQF52_RS21130 (LQF52_21130)	4669409..4669933	-	525	WP_039474562.1	hypothetical protein	Antitoxin
LQF52_RS21135 (LQF52_21135)	4670252..4672732	-	2481	WP_231051778.1	restriction endonuclease-like protein	-
LQF52_RS21140 (LQF52_21140)	4672751..4674406	-	1656	WP_231051779.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-265)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 296 a.a.
• Molecular weight: 33993.89 Da
• Isoelectric Point: 5.7070

>T226586 WP_039546397.1 NZ_CP088019:c4669380-4668493 [Pectobacterium carotovorum]
MLKQQIRQIVQSNPDYAAVTPVIEKEILHHDIIDVLIKQGVMQRLTFIGGTSLRMCYNSSRLSEDLDFNGGHDFQPSAFE
GLESEIQTYIQNKYETEVWVNKPSGAQQGDTVSWKISIVKEANRPDLPRQKMHIDVCAIPSFDIEKRPLINHYDIVVPTE
GILVPVQSLQETLADKLIALAYRARRIKPRDIWDIVWIKQRGIDLSKTLVEKKLTARQKQTEDFRQALSIQLAKLMSEDE
VRDDFNMEMSRFIPKQIKERTLDNPEYWAYVQGEVHTIASELLNDGTPKNPFDMG

Nucleotide

• Length: 888 bp

>T226586 NZ_CP122563:2634470-2634895 [Auritidibacter ignavus]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGACGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCCGATCAGTACCGCCGACGCGCAGAC
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA

Antitoxin

Protein

• Length: 175 a.a.
• Molecular weight: 19332.49 Da
• Isoelectric Point: 9.0504

>AT226586 WP_039474562.1 NZ_CP088019:c4669933-4669409 [Pectobacterium carotovorum]
MAKSDELLNALAKAVNAGGGIHSVTELAFMQGVPCDSAFRKFLADCVKKGLLRRVVKGFYESVITPPEPETAIYKIIKKL
RSGVLNYISLESQLSHTGDISQVVMGRVTVVTKGRSGCFDTPYGVIELTHTKKPVEQIAPNLYYDPDIKMYRAYKEQAIA
DLKHCQRNLHMLES

Nucleotide

• Length: 525 bp

>AT226586 NZ_CP122563:2634240-2634473 [Auritidibacter ignavus]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7V8PRU9