Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3150458..3151011 Replicon chromosome
Accession NZ_CP088019
Organism Pectobacterium carotovorum strain 25.1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A1V2R684
Locus tag LQF52_RS14340 Protein ID WP_039360030.1
Coordinates 3150458..3150772 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3I2T3
Locus tag LQF52_RS14345 Protein ID WP_014699357.1
Coordinates 3150775..3151011 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF52_RS14325 (LQF52_14325) 3147065..3147811 + 747 WP_039516895.1 MobC family replication-relaxation protein -
LQF52_RS14330 (LQF52_14330) 3148087..3148935 - 849 WP_039516894.1 hypothetical protein -
LQF52_RS14335 (LQF52_14335) 3149014..3149895 - 882 WP_039516893.1 hypothetical protein -
LQF52_RS14340 (LQF52_14340) 3150458..3150772 - 315 WP_039360030.1 CcdB family protein Toxin
LQF52_RS14345 (LQF52_14345) 3150775..3151011 - 237 WP_014699357.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LQF52_RS14350 (LQF52_14350) 3151330..3152274 - 945 WP_039516892.1 zincin-like metallopeptidase domain-containing protein -
LQF52_RS14355 (LQF52_14355) 3152897..3154087 + 1191 WP_039516891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3121935..3156791 34856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11535.48 Da        Isoelectric Point: 7.9859

>T226584 WP_039360030.1 NZ_CP088019:c3150772-3150458 [Pectobacterium carotovorum]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGF

Download         Length: 315 bp

>T226584 NZ_CP122561:29351-29776 [Auritidibacter ignavus]
GTGATCATCCTCGACACAAACGTGATCTCGGAGATCTTTCGACCCTTGCCCGAGCCACGCGTAGCGGACTGGCTCACGTC
CCTGGAGGGTGACGTAGCCATCACGTCCGTCACGCTCGCAGAACTGCTGGCAGGTTTGCGGCGGTTGCCGGATGGTCGGC
GCAGAGATGCGCTGACCAGACGAATTGATGTGGCGCTCGCACCGTACAGGGGCGGCCGCGCTGTGTTGCCGTTCGATGAC
GTGGCCGCCGACCGCTATGCCGACGTGCTCGTGGCTCGAGAGCGCGCGGGAGCGCAGATCAGTACCGCCGACGCGCAGAC
CGCCGCGATCTGCCTGGCGCACGGAGCAACCTGCGCTACGCGCAATGTGAAGGACTTCCAGCACACCGGCGTAGAACTGG
TGGATCCGTGGAAGGTCGATGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9004.06 Da        Isoelectric Point: 6.4610

>AT226584 WP_014699357.1 NZ_CP088019:c3151011-3150775 [Pectobacterium carotovorum]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRYHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT226584 NZ_CP122561:29121-29354 [Auritidibacter ignavus]
ATGTCATCCATCATCGTTCGCGGTCTCGACGACGCCGTGAAGCAGCAACTCGCTGCACAGGCGAAGGAGCACGGTCGGTC
GATGGAAGCCGAAGTTCGCGCCATCCTGACCAAAGCTGCACGCCGGCCGCACATAGGAATCGCTCTGCTGGCAGCCGCGC
AGGATGTCGGGGGAGTCGAGGAGCTACCGATCCCGGTGCGCGATGACGTCGCGCGGGCGGTGGACTTCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V2R684

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I2T3

References