Detailed information of TA system TA226583

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 1573505..1574304
• Replicon: chromosome
• Accession: NZ_CP088019
• Organism: Pectobacterium carotovorum strain 25.1

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: LQF52_RS07000
• Protein ID: WP_039544046.1
• Coordinates: 1573505..1573924 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: A0A7V8TEW6
• Locus tag: LQF52_RS07005
• Protein ID: WP_039544048.1
• Coordinates: 1573921..1574304 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF52_RS06980 (LQF52_06980)	1568615..1569256	+	642	WP_010296746.1	uridine kinase	-
LQF52_RS06985 (LQF52_06985)	1569364..1569945	+	582	WP_005974037.1	dCTP deaminase	-
LQF52_RS06990 (LQF52_06990)	1570009..1571844	+	1836	WP_231051964.1	outer membrane assembly protein AsmA	-
LQF52_RS06995 (LQF52_06995)	1572109..1573461	+	1353	WP_014914716.1	anaerobic C4-dicarboxylate transporter DcuC	-
LQF52_RS07000 (LQF52_07000)	1573505..1573924	-	420	WP_039544046.1	DUF86 domain-containing protein	Toxin
LQF52_RS07005 (LQF52_07005)	1573921..1574304	-	384	WP_039544048.1	nucleotidyltransferase domain-containing protein	Antitoxin
LQF52_RS07010 (LQF52_07010)	1574418..1576004	-	1587	WP_039544050.1	TerC family protein	-
LQF52_RS07015 (LQF52_07015)	1576738..1577790	+	1053	WP_039535351.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-
LQF52_RS07020 (LQF52_07020)	1577935..1579071	+	1137	WP_231051965.1	polysaccharide export protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (13-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (4-93)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 16010.29 Da
• Isoelectric Point: 6.9682

>T226583 WP_039544046.1 NZ_CP088019:c1573924-1573505 [Pectobacterium carotovorum]
MTDILLNKSSTIQRCLRRIREEFDTEEGFRQNFTKQDSVILNIQRACEAAIDIANYLIRIKQLGIPQSSRDSFALLAANQ
IITVDLSDNLQKMVGLRNIAVHDYQALNLDIVIHAISHRLSDFEHFIKQIARYSDSQHL

Nucleotide

• Length: 420 bp

>T226583 NZ_CP122540:c4783243-4782839 [Pseudomonas brenneri]
ATGATTAAATACATGCTTGATACCAACATTGTGATTTACATCATCAAGCGTAGGCCTATTGAAATACTCGAGAAATTCAA
TGCCAATGTTGGGCGTCTGGTGATTTCCTCAATCACCTTGGCTGAGCTCATGCATGGGGCCGAAAAAAGCCAGTTTGTTG
AGCGAAACACTCGAGCAGTGGAAGATTTCACCTCTCGGCTCGACATCATTCATTACGATGAGAAAGCCGCTTTTCACTAC
GGCTCAATTCGTTCCGACCTGGAAAAAAAGGGCACCCCCATTGGCGTCAATGACTTGCACATAGCCAGCCATGCCAGAAG
CTCTGGCCTGGTACTGGTGACGAACAACGAGGGTGAGTTCAAGCGCGTAAACGGCCTGCTTGTTGAAAACTGGATTGCTG
CCTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14386.60 Da
• Isoelectric Point: 4.7463

>AT226583 WP_039544048.1 NZ_CP088019:c1574304-1573921 [Pectobacterium carotovorum]
MFDKIVLTLKKQMPDIKIIYLFGSQATGNARADSDIDIAIMATRALDPIERWELSNQLAKEVGHDVDLIDLLQASTVLKM
EIVRNGKLLYDAETAAGEFEMTTLSMYQHLQKERADIIRSFNQDLKA

Nucleotide

• Length: 384 bp

>AT226583 NZ_CP122540:c4783475-4783236 [Pseudomonas brenneri]
ATGTCTACTGGAACAGTCTTTACAAATAACCGGACGCAAAATATCCGGATTCCGGCCGAATTGCGTTTCCCTGACGGCGT
GAAAACTGTCGAGGTCCGTGCCGTTGGGCGTGATTTGATCATCTCGCCGGTTGAAAACACATGGGACAGTTTTTTCCTTG
CTGGCGAATCAGTATCCGATGACTTTATGGCGGAGCGAACTGAACCGGCCCAGCAAGAGAGAGAGTCGTTTGATGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A7V8TEW6