Detailed information of TA system TA226582

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1351654..1352290
• Replicon: chromosome
• Accession: NZ_CP088019
• Organism: Pectobacterium carotovorum strain 25.1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A7V8QAU7
• Locus tag: LQF52_RS06000
• Protein ID: WP_039485998.1
• Coordinates: 1351654..1351836 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: LQF52_RS06005
• Protein ID: WP_039472423.1
• Coordinates: 1351859..1352290 (+)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF52_RS05975 (LQF52_05975)	1347006..1347209	+	204	WP_040031402.1	YbdD/YjiX family protein	-
LQF52_RS05980 (LQF52_05980)	1347226..1348212	+	987	WP_231051948.1	GTPase	-
LQF52_RS05985 (LQF52_05985)	1348494..1349876	+	1383	WP_039533323.1	glycosyl hydrolase family 28 protein	-
LQF52_RS05990 (LQF52_05990)	1350110..1350589	-	480	WP_119880747.1	Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK	-
LQF52_RS05995 (LQF52_05995)	1350660..1351478	-	819	WP_119880746.1	TraB/GumN family protein	-
LQF52_RS06000 (LQF52_06000)	1351654..1351836	+	183	WP_039485998.1	type II toxin-antitoxin system HicA family toxin	Toxin
LQF52_RS06005 (LQF52_06005)	1351859..1352290	+	432	WP_039472423.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LQF52_RS06010 (LQF52_06010)	1352385..1355108	-	2724	WP_231051949.1	copper-exporting P-type ATPase CopA	-
LQF52_RS06015 (LQF52_06015)	1355225..1355626	+	402	WP_119880744.1	Cu(I)-responsive transcriptional regulator	-
LQF52_RS06020 (LQF52_06020)	1355683..1356138	-	456	WP_010301274.1	NfeD family protein	-
LQF52_RS06025 (LQF52_06025)	1356138..1357052	-	915	WP_039486013.1	SPFH domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-138)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6539.74 Da
• Isoelectric Point: 10.5014

>T226582 WP_039485998.1 NZ_CP088019:1351654-1351836 [Pectobacterium carotovorum]
MKSTDLIKELAAAGCECKRHNGGSHQIWWSPITGKTFPVPHPKKDLPLGTVKSIKKMAGI

Nucleotide

• Length: 183 bp

>T226582 NZ_CP122540:3969811-3970155 [Pseudomonas brenneri]
ATGGATGCTCTATTTATCGAACTGCCGCCCTTTGAGCGGTACCGCAAGGACTACCTGACTGACGAACTGTTTCACGGCTT
TCAACAAGAGCTAATGAAGAACCCCGAAGCGGGAGCCGTGATGGAAGGCACCGGTGGGTTACGCAAGCTGCGCTTCGTCG
ATGAACGACGAAACAAAGGCAAGCGAGGTGGATTACGCGTCATCTACTACTGGTGGTCAGGCGGCACTCAATTTTGGCTG
TTCACGCTGTACGGCAAGCACGAGCAGAGCGACTTGAGCCCACAACACAAAAAAGCCCTCAAACACATGCTGGACAGGGA
AATCAAAGCGAGAGGATTCACATGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 16083.04 Da
• Isoelectric Point: 4.3145

>AT226582 WP_039472423.1 NZ_CP088019:1351859-1352290 [Pectobacterium carotovorum]
MFFSVGVETPKDDATAYGLIVPALCTDDYGCFSAADSQQEIARMAREAILTLIDEAVSRGNLDIKRLNDAGHLIYAAMPD
FADYDSWFVLDVDLSVFEGKPQRLNISLPDTLIQRIDNRVREQPGTYRDRSHFLAEAARHELE

Nucleotide

• Length: 432 bp

>AT226582 NZ_CP122540:3970152-3970466 [Pseudomonas brenneri]
ATGAACCGTGACATTTTTTCCGAACTGGTCGAAGGCTTCGATGCATTGGCCAATGAGCGCCAAGGCAAGGTCACACTACG
TACTCATACCGTGCAGCAAAACAAACTGGCCCCTCTCACCGCTGAAGACGTCATTGCAGTACGACAACAACTCAATCTTT
CCCGTGCTGTATTTGCCATGTACCTACGCACCAATACACGCACCCTGGAAAACTGGGAGCAAGGCCGCGCGCGACCTAAT
GCCCAGGCGGCCATACTGATTCGCCTGGTATCAAAGTTTCCGGATACGGTGGAACGATTGGCATTGCTAAGCTAA

Structures

Toxin

• AlphaFold DB: A0A7V8QAU7