Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 847759..848419 Replicon chromosome
Accession NZ_CP088019
Organism Pectobacterium carotovorum strain 25.1

Toxin (Protein)


Gene name cptA Uniprot ID A0A419ATT9
Locus tag LQF52_RS03845 Protein ID WP_029368427.1
Coordinates 848006..848419 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1D7Z1Z6
Locus tag LQF52_RS03840 Protein ID WP_005971623.1
Coordinates 847759..848025 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF52_RS03820 (LQF52_03820) 843737..844741 - 1005 WP_039543409.1 LacI family DNA-binding transcriptional regulator -
LQF52_RS03825 (LQF52_03825) 844796..845404 - 609 WP_014914174.1 HD domain-containing protein -
LQF52_RS03830 (LQF52_03830) 845683..846330 + 648 WP_039543413.1 hemolysin III family protein -
LQF52_RS03835 (LQF52_03835) 846522..847523 - 1002 WP_039534570.1 tRNA-modifying protein YgfZ -
LQF52_RS03840 (LQF52_03840) 847759..848025 + 267 WP_005971623.1 FAD assembly factor SdhE Antitoxin
LQF52_RS03845 (LQF52_03845) 848006..848419 + 414 WP_029368427.1 protein YgfX Toxin
LQF52_RS03850 (LQF52_03850) 848488..849423 + 936 WP_039534572.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
LQF52_RS03855 (LQF52_03855) 849506..849829 - 324 WP_039534575.1 hypothetical protein -
LQF52_RS03860 (LQF52_03860) 849858..850376 - 519 WP_039534579.1 flavodoxin FldB -
LQF52_RS03865 (LQF52_03865) 850716..851102 - 387 WP_039534581.1 thioesterase family protein -
LQF52_RS03870 (LQF52_03870) 851310..852638 - 1329 WP_010301826.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16296.29 Da        Isoelectric Point: 10.7911

>T226580 WP_029368427.1 NZ_CP088019:848006-848419 [Pectobacterium carotovorum]
VALWRCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDKQQLWLASDSMGDDEWRHLRQILLQQKHWAR

Download         Length: 414 bp

>T226580 NZ_CP088019:848006-848419 [Pectobacterium carotovorum]
GTGGCCCTGTGGCGATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGCCTATTAGTATT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTACGCGTGGCTATGGCTATGCCTGGTCACGATGGTGATGTTCGGTTTTA
TCCGTAGCCAACGGAATATTAAATCCCGACAGGGGGAAATCGTTCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAATGGCAGATCGTTAAACGACCGTGGCTGCTGAAGAATGGCGTATTACTGTCATTACAAGCGGTTAACGGTAAAGACAA
GCAACAGCTGTGGCTGGCATCGGACAGCATGGGCGATGATGAATGGCGTCACTTGCGTCAAATTCTTTTGCAGCAGAAAC
ACTGGGCAAGATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10507.94 Da        Isoelectric Point: 5.1392

>AT226580 WP_005971623.1 NZ_CP088019:847759-848025 [Pectobacterium carotovorum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT226580 NZ_CP088019:847759-848025 [Pectobacterium carotovorum]
ATGGAAATCGATAATAAATCACGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAATTGGATATCGCGATCATGCCGTT
TTTTGAGCATGACTATGACACACTTAATGACACTGATAAGCGCACGTTTGTACGCTTGTTACAAAGCGACGATCCCGATT
TATTCAACTGGCTGATGAACCACGGTGAACCGGAGGACGGAGAGCTGAAACGCATGATTTCCCTTATTCAGACGCGAAAT
AAAGATCGTGGCCCTGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A419ATT9

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z1Z6

References