Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 489105..490655 Replicon chromosome
Accession NZ_CP088019
Organism Pectobacterium carotovorum strain 25.1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LQF52_RS02200 Protein ID WP_040031921.1
Coordinates 489357..490655 (+) Length 433 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LQF52_RS02195 Protein ID WP_039491637.1
Coordinates 489105..489353 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF52_RS02170 (LQF52_02170) 484933..486276 + 1344 WP_040031918.1 HEAT repeat domain-containing protein -
LQF52_RS02175 (LQF52_02175) 486356..486640 + 285 WP_039546905.1 damage-inducible protein J -
LQF52_RS02180 (LQF52_02180) 486637..486942 + 306 WP_010296167.1 type II toxin-antitoxin system RelE/ParE family toxin -
LQF52_RS02185 (LQF52_02185) 486948..487739 - 792 WP_040031919.1 HNH endonuclease -
LQF52_RS02190 (LQF52_02190) 487893..488990 + 1098 WP_040031920.1 DUF1615 domain-containing protein -
LQF52_RS02195 (LQF52_02195) 489105..489353 + 249 WP_039491637.1 helix-turn-helix domain-containing protein Antitoxin
LQF52_RS02200 (LQF52_02200) 489357..490655 + 1299 WP_040031921.1 type II toxin-antitoxin system HipA family toxin Toxin
LQF52_RS02205 (LQF52_02205) 490792..492261 - 1470 WP_040031922.1 SulP family inorganic anion transporter -
LQF52_RS02210 (LQF52_02210) 492258..492926 - 669 WP_072036838.1 carbonic anhydrase -
LQF52_RS02215 (LQF52_02215) 493498..495447 - 1950 WP_039546919.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 433 a.a.        Molecular weight: 48476.62 Da        Isoelectric Point: 7.2480

>T226577 WP_040031921.1 NZ_CP088019:489357-490655 [Pectobacterium carotovorum]
MNILTVALNGIAVGALAKGVGSDMTFTYYPDWLSRPGARAISLSLPLQRATYRGDVVYNFFDNLLPDNDSIRSRIQARFR
IATKQPFDLLTSIGGDCVGAVQIYPVDTPVAPVTDVHAEALDNDEIEALLQGYREAPLGMAMDREDFRISLAGAQEKTAL
LWYKNQWHRPHGSTPTSHIFKLPIGYIANNSIDLSDSVENEWLCLKIAEKYGFTVAQAEISRFNSQKVLIVERFDRRWSR
SDKPWLMRLPQEDFCQALGIAPALKYESDGGPGIEKSMVLLLGSQQAMQDRDTFFKSQILFWMLAAIDGHAKNFSVFIEP
GSAYRMTPLYDVISAFPFMGPAGISVQKAKMAMAVLGRNRHFHWHKILPRHYFSSARQVGYPQERVAAMMSEMKANTERV
IAEVEALLPDDFPERISHPIFAGLRSQAARLP

Download         Length: 1299 bp

>T226577 NZ_CP122518:c55390-55241 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9332.57 Da        Isoelectric Point: 6.4835

>AT226577 WP_039491637.1 NZ_CP088019:489105-489353 [Pectobacterium carotovorum]
MKITSAGMLAHAMRDERKKHKLNQSQVAESMGIKQSTVSDFENHPEGTRLETLFKLLAALDLELHLSKRGEPQAGQEWSE
EW

Download         Length: 249 bp

>AT226577 NZ_CP122518:55434-55495 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References