Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 429126..429965 Replicon chromosome
Accession NZ_CP088019
Organism Pectobacterium carotovorum strain 25.1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LQF52_RS01915 Protein ID WP_039539484.1
Coordinates 429603..429965 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LQF52_RS01910 Protein ID WP_039470394.1
Coordinates 429126..429599 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF52_RS01895 (LQF52_01895) 424448..425371 - 924 WP_039546818.1 aminoimidazole riboside kinase -
LQF52_RS01900 (LQF52_01900) 425844..426395 + 552 WP_039546820.1 polymer-forming cytoskeletal protein -
LQF52_RS01905 (LQF52_01905) 426419..429136 + 2718 WP_119880602.1 CRISPR-associated helicase Cas3' -
LQF52_RS01910 (LQF52_01910) 429126..429599 - 474 WP_039470394.1 helix-turn-helix domain-containing protein Antitoxin
LQF52_RS01915 (LQF52_01915) 429603..429965 - 363 WP_039539484.1 type II toxin-antitoxin system HigB family toxin Toxin
LQF52_RS01920 (LQF52_01920) 430580..432148 + 1569 WP_231051823.1 type I-E CRISPR-associated protein Cse1/CasA -
LQF52_RS01925 (LQF52_01925) 432132..432779 + 648 WP_039507307.1 type I-E CRISPR-associated protein Cse2/CasB -
LQF52_RS01930 (LQF52_01930) 432783..433847 + 1065 WP_039507308.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
LQF52_RS01935 (LQF52_01935) 433857..434591 + 735 WP_039546825.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(74-111)

Antitoxin

Antitoxin HigA

(43-157)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14175.41 Da        Isoelectric Point: 9.7305

>T226576 WP_039539484.1 NZ_CP088019:c429965-429603 [Pectobacterium carotovorum]
MRVISAKAITDAMKKHAKWKVGLKLWLDVFDKPSLRFESYEQLCHVWRNTSCWNVDRIPFALLENESRKGPLDIYIFDIN
GNNCRIIAWLNPNTGSLYVKDVCSHAEYDKWWKAQTKTKR

Download         Length: 363 bp

>T226576 NZ_CP122517:c4554628-4554317 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17763.02 Da        Isoelectric Point: 4.2043

>AT226576 WP_039470394.1 NZ_CP088019:c429599-429126 [Pectobacterium carotovorum]
MRNTSLGSNSSVGISGLIENLPLLLQEASEQLNSLSVLLSACMEPIEDDNDLQERMECINQLYLYSSDVNDIPATFAELI
ADRVYEYEKKHRDVPHVSQAEALAFFIEERGLKQSDLKQIATQSVISDIINGKRTMTLQQVKDFSRYFNVPVETFID

Download         Length: 474 bp

>AT226576 NZ_CP122517:c4554316-4554026 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References