226574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 212950..213567 Replicon chromosome
Accession NZ_CP088019
Organism Pectobacterium carotovorum strain 25.1

Toxin (Protein)


Gene name hicA Uniprot ID C6DHN3
Locus tag LQF52_RS00905 Protein ID WP_010281507.1
Coordinates 213388..213567 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A426IL41
Locus tag LQF52_RS00900 Protein ID WP_039545938.1
Coordinates 212950..213360 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF52_RS00885 (LQF52_00885) 208843..209886 - 1044 WP_039363341.1 DNA-binding transcriptional regulator CytR -
LQF52_RS00890 (LQF52_00890) 210183..212381 - 2199 WP_231051816.1 primosomal protein N' -
LQF52_RS00895 (LQF52_00895) 212653..212868 + 216 WP_010281510.1 50S ribosomal protein L31 -
LQF52_RS00900 (LQF52_00900) 212950..213360 - 411 WP_039545938.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LQF52_RS00905 (LQF52_00905) 213388..213567 - 180 WP_010281507.1 type II toxin-antitoxin system HicA family toxin Toxin
LQF52_RS00910 (LQF52_00910) 213667..214677 - 1011 WP_039545936.1 iron ABC transporter permease -
LQF52_RS00915 (LQF52_00915) 214674..215636 - 963 WP_039545934.1 ABC transporter substrate-binding protein -
LQF52_RS00920 (LQF52_00920) 215646..216443 - 798 WP_039545932.1 ABC transporter ATP-binding protein -
LQF52_RS00925 (LQF52_00925) 216662..216979 - 318 WP_005973355.1 met regulon transcriptional regulator MetJ -
LQF52_RS00930 (LQF52_00930) 217167..218327 + 1161 WP_010299271.1 cystathionine gamma-synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6560.69 Da        Isoelectric Point: 10.7838

>T226574 WP_010281507.1 NZ_CP088019:c213567-213388 [Pectobacterium carotovorum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Download         Length: 180 bp

>T226574 NZ_CP122517:c4159154-4158804 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14533.41 Da        Isoelectric Point: 4.3391

>AT226574 WP_039545938.1 NZ_CP088019:c213360-212950 [Pectobacterium carotovorum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLIEMGQDIPTVSSVGQLAKNAEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Download         Length: 411 bp

>AT226574 NZ_CP122517:c4159399-4159148 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2I1S0

Antitoxin

Source ID Structure
AlphaFold DB A0A426IL41

References