Detailed information of TA system TA226573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataRT/DUF1778(antitoxin)
• Location: 151315..152066
• Replicon: chromosome
• Accession: NZ_CP088019
• Organism: Pectobacterium carotovorum strain 25.1

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: -
• Locus tag: LQF52_RS00635
• Protein ID: WP_039545981.1
• Coordinates: 151584..152066 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: LQF52_RS00630
• Protein ID: WP_039545984.1
• Coordinates: 151315..151593 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF52_RS00595 (LQF52_00595)	146854..147768	-	915	WP_014917036.1	NAD(P)-dependent oxidoreductase	-
LQF52_RS00600 (LQF52_00600)	148107..148868	+	762	WP_010303245.1	DNA-binding transcriptional repressor YgbI	-
LQF52_RS00605 (LQF52_00605)	148889..149218	-	330	WP_010303241.1	helix-turn-helix domain-containing protein	-
LQF52_RS00610 (LQF52_00610)	149169..149594	-	426	WP_052234750.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LQF52_RS00615 (LQF52_00615)	149805..149975	+	171	Protein_123	DeoR family transcriptional regulator	-
LQF52_RS00620 (LQF52_00620)	150092..150787	+	696	WP_039545988.1	hypothetical protein	-
LQF52_RS00625 (LQF52_00625)	150753..151205	+	453	WP_231051809.1	hypothetical protein	-
LQF52_RS00630 (LQF52_00630)	151315..151593	+	279	WP_039545984.1	DUF1778 domain-containing protein	Antitoxin
LQF52_RS00635 (LQF52_00635)	151584..152066	+	483	WP_039545981.1	GNAT family N-acetyltransferase	Toxin
LQF52_RS00640 (LQF52_00640)	152199..153533	+	1335	WP_039545979.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
LQF52_RS00645 (LQF52_00645)	153606..154493	+	888	WP_010303217.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
LQF52_RS00650 (LQF52_00650)	154490..155335	+	846	WP_010281598.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
LQF52_RS00655 (LQF52_00655)	155534..156607	+	1074	WP_039545977.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (39-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-92)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17479.28 Da
• Isoelectric Point: 9.0439

>T226573 WP_039545981.1 NZ_CP088019:151584-152066 [Pectobacterium carotovorum]
MGITAPEPLSSGHNLAEFCSQEPSLNEWLKKKALKNHSAGISRVYVICAEGTHQVIGYYCLSTGSVQRNTAPGAYRRNAP
ESLPVIVLGRLAIDQAYSGKGLGVALLKDAIFRTENIALQVGVRALVVHALDENVRNFYLKFAFDPSPVQPLMLLYPIKI

Nucleotide

• Length: 483 bp

>T226573 NZ_CP122517:3702989-3703267 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10639.11 Da
• Isoelectric Point: 4.4356

>AT226573 WP_039545984.1 NZ_CP088019:151315-151593 [Pectobacterium carotovorum]
MKPETKEAPINIRAKASQRDLIDMAANLVSKSRTDFMLEAACREAQDILLDQRLFILDNEQFDEFLAELDAPITTERQAR
INDLMSRKSPWE

Nucleotide

• Length: 279 bp

>AT226573 NZ_CP122517:3702726-3702986 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA