Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3461795..3462426 Replicon chromosome
Accession NZ_CP088018
Organism Ruania suaedae strain LR1S40

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQF12_RS15980 Protein ID WP_231053890.1
Coordinates 3462022..3462426 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQF12_RS15975 Protein ID WP_231053889.1
Coordinates 3461795..3462025 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF12_RS15960 (LQF12_15960) 3458075..3459046 - 972 WP_231053886.1 LacI family DNA-binding transcriptional regulator -
LQF12_RS15965 (LQF12_15965) 3459077..3460282 - 1206 WP_231053887.1 Gfo/Idh/MocA family oxidoreductase -
LQF12_RS15970 (LQF12_15970) 3460435..3461757 + 1323 WP_231053888.1 L-fucose:H+ symporter permease -
LQF12_RS15975 (LQF12_15975) 3461795..3462025 + 231 WP_231053889.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQF12_RS15980 (LQF12_15980) 3462022..3462426 + 405 WP_231053890.1 type II toxin-antitoxin system VapC family toxin Toxin
LQF12_RS15985 (LQF12_15985) 3462428..3463027 - 600 WP_231053891.1 YdeI/OmpD-associated family protein -
LQF12_RS15990 (LQF12_15990) 3463096..3464055 - 960 WP_231053892.1 NAD-dependent epimerase/dehydratase family protein -
LQF12_RS15995 (LQF12_15995) 3464164..3464973 + 810 WP_231053893.1 hydrolase -
LQF12_RS16000 (LQF12_16000) 3464992..3465726 - 735 WP_231053894.1 hypothetical protein -
LQF12_RS16005 (LQF12_16005) 3465791..3466966 + 1176 WP_231053895.1 Gfo/Idh/MocA family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(6-51)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14626.77 Da        Isoelectric Point: 5.1993

>T226572 WP_231053890.1 NZ_CP088018:3462022-3462426 [Ruania suaedae]
VSTLYLLDTNVLVALLRGQAERAHPRLRAAEGRIAVSTISEMQLEYGVERSQEPLRNRQAVDELLSLVEILEFDTIAAMH
AGRIRAVLASAGAPIGPFDSLLAGHARSLGLVLVTNNTREFTRVPGLEVEDWLA

Download         Length: 405 bp

>T226572 NZ_CP122517:3521393-3521935 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8620.63 Da        Isoelectric Point: 7.0148

>AT226572 WP_231053889.1 NZ_CP088018:3461795-3462025 [Ruania suaedae]
MRSTVFRNNRTQAVRLPKAAALPEDVREVNVRVIGRSRVIEPVGSSWDEWFEHGLRTSADFLADRDQGTAEERPGL

Download         Length: 231 bp

>AT226572 NZ_CP122517:3521098-3521409 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References