Detailed information of TA system TA226570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1457221..1457882
• Replicon: chromosome
• Accession: NZ_CP088018
• Organism: Ruania suaedae strain LR1S40

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LQF12_RS06720
• Protein ID: WP_231055195.1
• Coordinates: 1457484..1457882 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LQF12_RS06715
• Protein ID: WP_231055194.1
• Coordinates: 1457221..1457487 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF12_RS06685 (LQF12_06685)	1452283..1453179	+	897	WP_231055545.1	RNA methyltransferase	-
LQF12_RS06690 (LQF12_06690)	1453205..1453879	+	675	WP_231055190.1	nucleoside/nucleotide kinase family protein	-
LQF12_RS06695 (LQF12_06695)	1453896..1454402	-	507	WP_231055191.1	hypothetical protein	-
LQF12_RS06700 (LQF12_06700)	1454439..1455437	+	999	WP_231055192.1	hypothetical protein	-
LQF12_RS06705 (LQF12_06705)	1455434..1456042	+	609	WP_231055193.1	RNA 2',3'-cyclic phosphodiesterase	-
LQF12_RS06710 (LQF12_06710)	1456134..1457162	+	1029	WP_231055546.1	ATP-dependent DNA ligase	-
LQF12_RS06715 (LQF12_06715)	1457221..1457487	+	267	WP_231055194.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LQF12_RS06720 (LQF12_06720)	1457484..1457882	+	399	WP_231055195.1	type II toxin-antitoxin system VapC family toxin	Toxin
LQF12_RS06725 (LQF12_06725)	1457912..1458958	-	1047	WP_231055196.1	non-homologous end-joining DNA ligase	-
LQF12_RS06730 (LQF12_06730)	1459053..1460141	-	1089	WP_231055197.1	PLP-dependent aminotransferase family protein	-
LQF12_RS06735 (LQF12_06735)	1460216..1462162	+	1947	WP_231055198.1	DUF5107 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-87)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13753.57 Da
• Isoelectric Point: 4.4596

>T226570 WP_231055195.1 NZ_CP088018:1457484-1457882 [Ruania suaedae]
MIVDTSALVAVLLGEGDAEAIADALARGPVRISAATLVEARVVLLATVGPEGRRRLDALLQEAEVEVVPTDAAQADIAAD
AYRDYGKGTGHPAALNLGDCFSYALATARREPLLYKGENFSHTDVRPALPGA

Nucleotide

• Length: 399 bp

>T226570 NZ_CP122517:2683200-2683307 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9802.00 Da
• Isoelectric Point: 5.1239

>AT226570 WP_231055194.1 NZ_CP088018:1457221-1457487 [Ruania suaedae]
MGLNIKNEDTSALVRQLAEMLGTSQVGAVEDAVRHRLAEVRATGDYQRVRSQAILELGAEFRRRLTPAQIDALRHAEDDL
YDDAGLPR

Nucleotide

• Length: 267 bp

>AT226570 NZ_CP122517:c2683150-2683087 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT