226564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4002575..4003131 Replicon chromosome
Accession NZ_CP088010
Organism Rhizobium sp. T136

Toxin (Protein)


Gene name parE Uniprot ID W6RNT9
Locus tag LPB79_RS29590 Protein ID WP_024313433.1
Coordinates 4002575..4002865 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W6R6C2
Locus tag LPB79_RS29595 Protein ID WP_024313432.1
Coordinates 4002853..4003131 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB79_RS29565 (LPB79_29565) 3998300..3998650 + 351 WP_024313437.1 hypothetical protein -
LPB79_RS29570 (LPB79_29570) 3998823..4000127 + 1305 WP_024313436.1 nicotinate phosphoribosyltransferase -
LPB79_RS29575 (LPB79_29575) 4000262..4000657 + 396 WP_024313435.1 hypothetical protein -
LPB79_RS29580 (LPB79_29580) 4000788..4001309 + 522 WP_024313434.1 peptide-methionine (S)-S-oxide reductase MsrA -
LPB79_RS29585 (LPB79_29585) 4001508..4002485 + 978 Protein_3979 nucleotidyltransferase and HEPN domain-containing protein -
LPB79_RS29590 (LPB79_29590) 4002575..4002865 - 291 WP_024313433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPB79_RS29595 (LPB79_29595) 4002853..4003131 - 279 WP_024313432.1 CopG family ribbon-helix-helix protein Antitoxin
LPB79_RS29605 (LPB79_29605) 4004046..4004363 + 318 WP_024313431.1 hypothetical protein -
LPB79_RS29610 (LPB79_29610) 4004678..4005670 + 993 WP_024313430.1 BMP family ABC transporter substrate-binding protein -
LPB79_RS29615 (LPB79_29615) 4005739..4007250 + 1512 WP_024313429.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11064.82 Da        Isoelectric Point: 8.4843

>T226564 WP_024313433.1 NZ_CP088010:c4002865-4002575 [Rhizobium sp. T136]
MPQIIFSPAAVRDLERLREFLRPKNPLAAKRAGETILKGLRALGAHPYMGRLVEDLPDQYREWLIDFGDSGYLARYRIDE
DILTVLAVRHQKEVGF

Download         Length: 291 bp

>T226564 NZ_CP122517:1823353-1823607 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10862.01 Da        Isoelectric Point: 4.8227

>AT226564 WP_024313432.1 NZ_CP088010:c4003131-4002853 [Rhizobium sp. T136]
MASPTSLKLDDELKGRVQHLAEVRRRSSHWIMREAIEQYVEREEKREALRSETLNAWDEFQETGLHVTGDEVEKWLSTWG
TDDERAPPECHK

Download         Length: 279 bp

>AT226564 NZ_CP122517:1823105-1823356 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6RNT9

Antitoxin

Source ID Structure
AlphaFold DB W6R6C2

References