Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 5286152..5286795 Replicon chromosome
Accession NZ_CP088008
Organism Tardiphaga sp. 37S4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPB73_RS25045 Protein ID WP_120287747.1
Coordinates 5286406..5286795 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPB73_RS25040 Protein ID WP_175369421.1
Coordinates 5286152..5286391 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPB73_RS25020 (LPB73_25020) 5281554..5282507 - 954 WP_093757898.1 LysR family transcriptional regulator -
LPB73_RS25025 (LPB73_25025) 5282626..5283627 + 1002 WP_231078568.1 aldo/keto reductase -
LPB73_RS25030 (LPB73_25030) 5283693..5284493 - 801 WP_231078569.1 molybdopterin-synthase adenylyltransferase MoeB -
LPB73_RS25035 (LPB73_25035) 5284728..5286089 + 1362 WP_231078570.1 serine protease -
LPB73_RS25040 (LPB73_25040) 5286152..5286391 + 240 WP_175369421.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LPB73_RS25045 (LPB73_25045) 5286406..5286795 + 390 WP_120287747.1 type II toxin-antitoxin system VapC family toxin Toxin
LPB73_RS25050 (LPB73_25050) 5286816..5287493 - 678 WP_089266426.1 PilZ domain-containing protein -
LPB73_RS25055 (LPB73_25055) 5287659..5288456 - 798 WP_089266425.1 class I SAM-dependent methyltransferase -
LPB73_RS25060 (LPB73_25060) 5288639..5289739 + 1101 WP_231078571.1 pyrimidine utilization protein A -
LPB73_RS25065 (LPB73_25065) 5289789..5290670 - 882 WP_231078572.1 bifunctional DNA-formamidopyrimidine glycosylase/DNA-(apurinic or apyrimidinic site) lyase -
LPB73_RS25070 (LPB73_25070) 5290765..5291526 + 762 WP_231081248.1 bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-121)

Antitoxin

SpoVT-AbrB domain

(10-47)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14133.37 Da        Isoelectric Point: 8.2839

>T226561 WP_120287747.1 NZ_CP088008:5286406-5286795 [Tardiphaga sp. 37S4]
MLDTNVVSDLIRNPAGRVAKRIRKLGAEGFCVSIITSAELRFGCAKRNSPRLTQLVEQVLNELDILPLESPADTEYARIR
HDLEKKGVPIGPNDLLIAAHACAVDATLVTANAKEFKRVSGLKVENWLS

Download         Length: 390 bp

>T226561 NZ_CP122517:1008924-1009259 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9137.52 Da        Isoelectric Point: 5.7118

>AT226561 WP_175369421.1 NZ_CP088008:5286152-5286391 [Tardiphaga sp. 37S4]
MTDSRHVRLFRNGRNQAVRIPVEFELPGDEAVMHRDGDRLVIEPVRKRGLLALLDTMEPFTEEFPDVDAGLRPLRDIKL

Download         Length: 240 bp

>AT226561 NZ_CP122517:1008676-1008924 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References