226559

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 6795291..6795925 Replicon chromosome
Accession NZ_CP088007
Organism Nocardia huaxiensis strain BCHNH01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LPY97_RS31260 Protein ID WP_231083982.1
Coordinates 6795506..6795925 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LPY97_RS31255 Protein ID WP_181582778.1
Coordinates 6795291..6795515 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPY97_RS31240 (LPY97_31240) 6792296..6792586 - 291 WP_181582775.1 YiaA/YiaB family inner membrane protein -
LPY97_RS31245 (LPY97_31245) 6792739..6794508 + 1770 WP_231083980.1 alpha/beta hydrolase -
LPY97_RS31250 (LPY97_31250) 6794569..6795213 + 645 WP_231083981.1 CPBP family glutamic-type intramembrane protease -
LPY97_RS31255 (LPY97_31255) 6795291..6795515 + 225 WP_181582778.1 ribbon-helix-helix protein, CopG family Antitoxin
LPY97_RS31260 (LPY97_31260) 6795506..6795925 + 420 WP_231083982.1 PIN domain nuclease Toxin
LPY97_RS31265 (LPY97_31265) 6795940..6796326 + 387 WP_181582780.1 sterol carrier family protein -
LPY97_RS31270 (LPY97_31270) 6796361..6797593 - 1233 WP_181585290.1 DUF3533 domain-containing protein -
LPY97_RS31275 (LPY97_31275) 6797814..6799379 + 1566 WP_181582781.1 amidophosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-39)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15069.11 Da        Isoelectric Point: 4.7791

>T226559 WP_231083982.1 NZ_CP088007:6795506-6795925 [Nocardia huaxiensis]
MGVTEWLIDKSALVRLSGSPDIDVWAERIDQGRVRVATVTRLEVGFSARSGPDHRAAFSRPPLSSFLVEYLTPTMEDRAL
EVQAALADAGHHRAPSVADLLVAAVAELSGLTVLHLDKDFELIADVTGQPVERLRLSGE

Download         Length: 420 bp

>T226559 NZ_CP122517:c602051-601587 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8424.52 Da        Isoelectric Point: 4.5917

>AT226559 WP_181582778.1 NZ_CP088007:6795291-6795515 [Nocardia huaxiensis]
MSADLLIRDVPDDVIAAIDAKAKRLGLSRTQYLRRTLAREAASDERRVTAADLVWFSDTFADLADEEVMRRAWE

Download         Length: 225 bp

>AT226559 NZ_CP122517:c602386-602051 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References