226555

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1658607..1659116 Replicon chromosome
Accession NZ_CP088002
Organism Staphylococcus epidermidis strain IVK83

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag LQF30_RS08045 Protein ID WP_001829980.1
Coordinates 1658607..1658816 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag LQF30_RS08050 Protein ID WP_001829893.1
Coordinates 1658823..1659116 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF30_RS08025 (LQF30_08010) 1654186..1655541 - 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
LQF30_RS08030 (LQF30_08015) 1655553..1656626 - 1074 WP_002468311.1 D-alanine--D-alanine ligase -
LQF30_RS08035 (LQF30_08020) 1657017..1658228 + 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
LQF30_RS08040 (LQF30_08025) 1658327..1658464 - 138 WP_001829949.1 Lmo0850 family protein -
LQF30_RS08045 (LQF30_08030) 1658607..1658816 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
LQF30_RS08050 (LQF30_08035) 1658823..1659116 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
LQF30_RS08055 (LQF30_08040) 1659290..1660774 + 1485 WP_002457116.1 cardiolipin synthase -
LQF30_RS08060 (LQF30_08045) 1660956..1661609 + 654 WP_001829983.1 HD domain-containing protein -
LQF30_RS08065 (LQF30_08050) 1661715..1662587 - 873 WP_002458703.1 membrane protein insertase YidC -
LQF30_RS08070 (LQF30_08055) 1662676..1663314 - 639 WP_002505076.1 thiamine phosphate synthase -
LQF30_RS08075 (LQF30_08060) 1663320..1664108 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T226555 WP_001829980.1 NZ_CP088002:c1658816-1658607 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T226555 NZ_CP122515:1146105-1146371 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATTTGGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT226555 WP_001829893.1 NZ_CP088002:c1659116-1658823 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT226555 NZ_CP122515:1145747-1146124 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGTGCTTAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGTGTTAGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References