Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 1647402..1647931 | Replicon | chromosome |
| Accession | NZ_CP088002 | ||
| Organism | Staphylococcus epidermidis strain IVK83 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | Q5HME7 |
| Locus tag | LQF30_RS07985 | Protein ID | WP_001829891.1 |
| Coordinates | 1647402..1647764 (-) | Length | 121 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | Q5HME6 |
| Locus tag | LQF30_RS07990 | Protein ID | WP_001829931.1 |
| Coordinates | 1647761..1647931 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LQF30_RS07965 (LQF30_07950) | 1644404..1645174 | - | 771 | WP_002440602.1 | RNA polymerase sigma factor SigB | - |
| LQF30_RS07970 (LQF30_07955) | 1645149..1645628 | - | 480 | WP_038398573.1 | anti-sigma B factor RsbW | - |
| LQF30_RS07975 (LQF30_07960) | 1645630..1645956 | - | 327 | WP_001829952.1 | anti-sigma factor antagonist | - |
| LQF30_RS07980 (LQF30_07965) | 1646056..1647057 | - | 1002 | WP_001829902.1 | PP2C family protein-serine/threonine phosphatase | - |
| LQF30_RS07985 (LQF30_07970) | 1647402..1647764 | - | 363 | WP_001829891.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| LQF30_RS07990 (LQF30_07975) | 1647761..1647931 | - | 171 | WP_001829931.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| LQF30_RS07995 (LQF30_07980) | 1648018..1649166 | - | 1149 | WP_002457107.1 | alanine racemase | - |
| LQF30_RS08000 (LQF30_07985) | 1649233..1649586 | - | 354 | WP_107511248.1 | holo-ACP synthase | - |
| LQF30_RS08005 (LQF30_07990) | 1649634..1650143 | - | 510 | WP_002457109.1 | PH domain-containing protein | - |
| LQF30_RS08010 (LQF30_07995) | 1650130..1651635 | - | 1506 | WP_002457110.1 | PH domain-containing protein | - |
| LQF30_RS08015 (LQF30_08000) | 1651628..1652107 | - | 480 | WP_002457111.1 | PH domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13497.65 Da Isoelectric Point: 9.9522
>T226554 WP_001829891.1 NZ_CP088002:c1647764-1647402 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS
Download Length: 363 bp
>T226554 NZ_CP122515:582026-582790 [Helicobacter pylori]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGTGAAAAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATAGTTACAATTCTATTTGTGATTGGTTTTTGT
GGAGAATTGCATATAATACAGAGATTAGCTTCTAAATATTTTTAA
ATGGAAATTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGTGAAAAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACGCTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGAACTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAACAAACACAATACATAACCATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAGAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATAGTTACAATTCTATTTGTGATTGGTTTTTGT
GGAGAATTGCATATAATACAGAGATTAGCTTCTAAATATTTTTAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6289.92 Da Isoelectric Point: 4.1920
>AT226554 WP_001829931.1 NZ_CP088002:c1647931-1647761 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE
Download Length: 171 bp
>AT226554 NZ_CP122515:581599-582036 [Helicobacter pylori]
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAGATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA
ATGGTCAATACTTTGGAACTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGTAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCTAAAGAAGAAACGCTC
TCACAAGATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAAAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2G7HWR0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N1EF65 |