226553

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1502768..1503570 Replicon chromosome
Accession NZ_CP088002
Organism Staphylococcus epidermidis strain IVK83

Toxin (Protein)


Gene name tsbT Uniprot ID Q5HN83
Locus tag LQF30_RS07155 Protein ID WP_002468490.1
Coordinates 1502768..1502947 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID Q5HN82
Locus tag LQF30_RS07160 Protein ID WP_002456349.1
Coordinates 1502971..1503570 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQF30_RS07135 (LQF30_07120) 1498161..1499294 - 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -
LQF30_RS07140 (LQF30_07125) 1499453..1500277 + 825 WP_001829804.1 RluA family pseudouridine synthase -
LQF30_RS07145 (LQF30_07130) 1500638..1502023 - 1386 WP_001829862.1 class II fumarate hydratase -
LQF30_RS07150 (LQF30_07135) 1502208..1502612 - 405 WP_001829818.1 hypothetical protein -
LQF30_RS07155 (LQF30_07140) 1502768..1502947 - 180 WP_002468490.1 SAS053 family protein Toxin
LQF30_RS07160 (LQF30_07145) 1502971..1503570 - 600 WP_002456349.1 glucosamine-6-phosphate isomerase Antitoxin
LQF30_RS07165 (LQF30_07150) 1503728..1504198 - 471 WP_001829836.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LQF30_RS07170 (LQF30_07155) 1504195..1505325 - 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
LQF30_RS07175 (LQF30_07160) 1505404..1505690 - 287 Protein_1398 hypothetical protein -
LQF30_RS07180 (LQF30_07165) 1506187..1506909 - 723 WP_001829838.1 amino acid ABC transporter ATP-binding protein -
LQF30_RS07185 (LQF30_07170) 1506902..1508358 - 1457 Protein_1400 ABC transporter substrate-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6963.56 Da        Isoelectric Point: 4.3016

>T226553 WP_002468490.1 NZ_CP088002:c1502947-1502768 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQSHDNEVRSDLKKQ

Download         Length: 180 bp

>T226553 NZ_CP122514:12111-12392 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCACTTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22709.62 Da        Isoelectric Point: 4.9942

>AT226553 WP_002456349.1 NZ_CP088002:c1503570-1502971 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHTVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT226553 NZ_CP122514:11870-12121 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HY44

Antitoxin

Source ID Structure
AlphaFold DB A0A5E9LUD0

References