Detailed information of TA system TA226552

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 530155..530625
• Replicon: chromosome
• Accession: NZ_CP088002
• Organism: Staphylococcus epidermidis strain IVK83

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q5HQS5
• Locus tag: LQF30_RS02685
• Protein ID: WP_001829569.1
• Coordinates: 530155..530343 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: D4FNP2
• Locus tag: LQF30_RS02690
• Protein ID: WP_002438963.1
• Coordinates: 530368..530625 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LQF30_RS02655 (LQF30_02655)	526635..526835	+	201	WP_001829681.1	cold-shock protein	-
LQF30_RS02660 (LQF30_02660)	527456..527680	-	225	WP_001829613.1	hypothetical protein	-
LQF30_RS02665 (LQF30_02665)	527704..527988	-	285	WP_001829635.1	hypothetical protein	-
LQF30_RS02670 (LQF30_02670)	528087..528833	-	747	WP_258499966.1	poly-gamma-glutamate hydrolase family protein	-
LQF30_RS02675 (LQF30_02675)	529118..529351	+	234	WP_001829664.1	hypothetical protein	-
LQF30_RS02680 (LQF30_02680)	529411..529965	-	555	WP_001829566.1	lipoprotein N-acylation protein LnsA	-
LQF30_RS02685 (LQF30_02685)	530155..530343	-	189	WP_001829569.1	hypothetical protein	Toxin
LQF30_RS02690 (LQF30_02690)	530368..530625	-	258	WP_002438963.1	hypothetical protein	Antitoxin
LQF30_RS02695 (LQF30_02695)	531034..531237	+	204	WP_002438966.1	sterile alpha motif-like domain-containing protein	-
LQF30_RS02700 (LQF30_02700)	531229..531465	-	237	WP_002457224.1	hypothetical protein	-
LQF30_RS02705 (LQF30_02705)	531679..532266	+	588	WP_038399226.1	histidine phosphatase family protein	-
LQF30_RS02710 (LQF30_02710)	532537..533037	-	501	WP_001829623.1	GNAT family N-acetyltransferase	-
LQF30_RS02715 (LQF30_02715)	533423..533610	+	188	Protein_519	hypothetical protein	-
LQF30_RS02720 (LQF30_02720)	533962..534384	-	423	WP_263927731.1	organic hydroperoxide resistance protein	-
LQF30_RS02725 (LQF30_02725)	534545..535261	+	717	WP_258499962.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7229.94 Da
• Isoelectric Point: 9.7844

>T226552 WP_001829569.1 NZ_CP088002:c530343-530155 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Nucleotide

• Length: 189 bp

>T226552 NZ_CP122512:20951-21232 [Escherichia coli]
ATGATTTATGAACTGGCATTTGACCACAGAGCACTGAAGGAATGGCAAAAACTCGGTCACACTGTTCGTGAGCAATTCAA
AAAGAAACTGTCAGAACGCCTGATAAATCCACGCGTCCCCGCAGCCAAGCTACATGGTCATACTGACCGTTACAAAATTA
AGCTTCGCGCATCCGGTTACAGGCTCGTTTATCAGGTAATTGATGAGAAGGTCGTTTTGCTTGTGATTTCTGTGGGAAAA
AGAGAAGGCAGCGACGTCTATCACATGGCAGATACCCGCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10014.05 Da
• Isoelectric Point: 4.5440

>AT226552 WP_002438963.1 NZ_CP088002:c530625-530368 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Nucleotide

• Length: 258 bp

>AT226552 NZ_CP122512:20710-20961 [Escherichia coli]
ATGAGCTACCAAATTCTGACTACGACAGCAGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACTGTAGCCGAAGG
AGAAGGGGATGCCGTCGCAATCCTGAACCGAAATGAACCAGCGTTCTACTGTGTCCCACCAGAACTTTATGCCTACTACC
GGGAACTCGCTGAAGACGCTGAACTCAACGCAATTGCTGATGAAAGAATGAAAAATCCAGACATTGTAAGGGTTAACCTG
GATGATTTATGA

Structures

Toxin

• AlphaFold DB: A0A0N0LUH8

Antitoxin

• AlphaFold DB: A0A0U5IVM3