Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 4218782..4219353 Replicon chromosome
Accession NZ_CP087999
Organism Geomonas sp. RF6

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LPW11_RS18035 Protein ID WP_230995262.1
Coordinates 4218782..4219036 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LPW11_RS18040 Protein ID WP_230995263.1
Coordinates 4219030..4219353 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPW11_RS18015 (LPW11_18015) 4213886..4215250 - 1365 WP_230995258.1 hypothetical protein -
LPW11_RS18020 (LPW11_18020) 4215880..4216239 - 360 WP_230995259.1 hypothetical protein -
LPW11_RS18025 (LPW11_18025) 4216466..4217215 + 750 WP_230995260.1 ATP-binding cassette domain-containing protein -
LPW11_RS18030 (LPW11_18030) 4217212..4218723 + 1512 WP_230995261.1 glycine betaine ABC transporter substrate-binding protein -
LPW11_RS18035 (LPW11_18035) 4218782..4219036 + 255 WP_230995262.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
LPW11_RS18040 (LPW11_18040) 4219030..4219353 + 324 WP_230995263.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
LPW11_RS18045 (LPW11_18045) 4219553..4219957 + 405 WP_230995264.1 PQ-loop domain-containing transporter -
LPW11_RS18050 (LPW11_18050) 4219885..4223307 - 3423 WP_230995265.1 IscS subfamily cysteine desulfurase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(7-48)

Antitoxin

mRNA interferase PemK-like

(4-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9803.10 Da        Isoelectric Point: 4.3813

>T226545 WP_230995262.1 NZ_CP087999:4218782-4219036 [Geomonas sp. RF6]
MRASIIRIGNSQGIRIPKLLLEQTRLGSEVELEVEDDKIVIRPVSRPRQGWLEKFKLMAEQGDDRLLDPGAGEETEWDKD
EWEW

Download         Length: 255 bp

>T226545 NZ_CP122509:c33147-32731 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12073.23 Da        Isoelectric Point: 9.9794

>AT226545 WP_230995263.1 NZ_CP087999:4219030-4219353 [Geomonas sp. RF6]
MVTKRFEVYLVNLDPTVGSEIRKARPCLIISPDEMNRFLATVIVAPMTTKGRDYPTRVPCSFKGKDGHVVLDQLRTVDKI
RLVQKLGKVKPQTQQDVLAVLSDMFAE

Download         Length: 324 bp

>AT226545 NZ_CP122509:c33374-33144 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References