Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 2737724..2738204 Replicon chromosome
Accession NZ_CP087999
Organism Geomonas sp. RF6

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag LPW11_RS11770 Protein ID WP_230994085.1
Coordinates 2737932..2738204 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag LPW11_RS11765 Protein ID WP_230994084.1
Coordinates 2737724..2737948 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LPW11_RS11750 (LPW11_11750) 2732843..2733889 - 1047 WP_230994081.1 M48 family metallopeptidase -
LPW11_RS11755 (LPW11_11755) 2733886..2735184 - 1299 WP_230994082.1 DUF898 family protein -
LPW11_RS11760 (LPW11_11760) 2735613..2737646 + 2034 WP_230994083.1 UvrD-helicase domain-containing protein -
LPW11_RS11765 (LPW11_11765) 2737724..2737948 + 225 WP_230994084.1 DUF6290 family protein Antitoxin
LPW11_RS11770 (LPW11_11770) 2737932..2738204 + 273 WP_230994085.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LPW11_RS11775 (LPW11_11775) 2738251..2738856 - 606 WP_269145334.1 peroxiredoxin -
LPW11_RS11780 (LPW11_11780) 2739040..2739555 + 516 WP_230994086.1 peptidylprolyl isomerase -
LPW11_RS11785 (LPW11_11785) 2739822..2740991 + 1170 WP_230994087.1 methionine adenosyltransferase -
LPW11_RS11790 (LPW11_11790) 2741075..2741776 - 702 WP_230994088.1 response regulator transcription factor -
LPW11_RS11795 (LPW11_11795) 2741783..2742739 - 957 WP_230994089.1 HAMP domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin

Protein of unknown function DUF6290

(3-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10624.41 Da        Isoelectric Point: 10.6484

>T226544 WP_230994085.1 NZ_CP087999:2737932-2738204 [Geomonas sp. RF6]
MSWKIEFSPAAKRELDRLDRPIARRILNFLSERVSKLDDPRAMGAALKGPHLGEFWKYRIGDYRIIAKIEDSQLLILVLR
VGNRRDIYER

Download         Length: 273 bp

>T226544 NZ_CP122509:21224-21499 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATTTGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8587.82 Da        Isoelectric Point: 4.1860

>AT226544 WP_230994084.1 NZ_CP087999:2737724-2737948 [Geomonas sp. RF6]
MLAIDLPEDIQMRLDRLAKATGRPKSFYAREAIIEYLDDLEDAYLAEKELAEIRAGKAKTIPLEEVMREYELED

Download         Length: 225 bp

>AT226544 NZ_CP122509:20940-21224 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References