Detailed information of TA system TA226543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 2725972..2726531
• Replicon: chromosome
• Accession: NZ_CP087999
• Organism: Geomonas sp. RF6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LPW11_RS11735
• Protein ID: WP_230998280.1
• Coordinates: 2725972..2726337 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LPW11_RS11740
• Protein ID: WP_230994079.1
• Coordinates: 2726340..2726531 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LPW11_RS11715 (LPW11_11715)	2721415..2721999	+	585	WP_230994075.1	hypothetical protein	-
LPW11_RS11720 (LPW11_11720)	2722241..2722414	-	174	WP_230994076.1	hypothetical protein	-
LPW11_RS11725 (LPW11_11725)	2722471..2723283	-	813	WP_230994077.1	polysaccharide deacetylase family protein	-
LPW11_RS11730 (LPW11_11730)	2723891..2725897	-	2007	WP_230994078.1	NAD-dependent DNA ligase LigA	-
LPW11_RS11735 (LPW11_11735)	2725972..2726337	-	366	WP_230998280.1	type II toxin-antitoxin system VapC family toxin	Toxin
LPW11_RS11740 (LPW11_11740)	2726340..2726531	-	192	WP_230994079.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-111)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-47)

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13053.12 Da
• Isoelectric Point: 5.4713

>T226543 WP_230998280.1 NZ_CP087999:c2726337-2725972 [Geomonas sp. RF6]
MVLVDTSVWIDHLRSSNAGLVALLEEGTVLCHPFVVGEVACGNLRQRETVLALLNALPVAAEAQHHEVLLFLERHQLFGK
GVGLIDIHLLASAALSGARIWTLDQRVAEAAETLGLSCRPE

Nucleotide

• Length: 366 bp

>T226543 NZ_CP122508:153680-154096 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 6967.04 Da
• Isoelectric Point: 10.2947

>AT226543 WP_230994079.1 NZ_CP087999:c2726531-2726340 [Geomonas sp. RF6]
MRTTMNIDDALLDTASRLTGVTEKTALVKLGLQALIARESARRLAELGGSEKELEDIPRRKSR

Nucleotide

• Length: 192 bp

>AT226543 NZ_CP122508:153453-153683 [Escherichia coli]
ATGAGAACCGTATCGATATTCAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA