Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4267592..4268283 Replicon chromosome
Accession NZ_CP087997
Organism Subtercola sp. AK-R2A1-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ955_RS19795 Protein ID WP_231026177.1
Coordinates 4267846..4268283 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQ955_RS19790 Protein ID WP_231026176.1
Coordinates 4267592..4267849 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ955_RS19770 (LQ955_19770) 4263450..4264691 + 1242 WP_231026172.1 beta-ketoacyl-[acyl-carrier-protein] synthase family protein -
LQ955_RS19775 (LQ955_19775) 4265067..4266053 - 987 WP_231026173.1 Gfo/Idh/MocA family oxidoreductase -
LQ955_RS19780 (LQ955_19780) 4266077..4266457 - 381 WP_231026174.1 hypothetical protein -
LQ955_RS19785 (LQ955_19785) 4266536..4267465 + 930 WP_231026175.1 alpha/beta hydrolase -
LQ955_RS19790 (LQ955_19790) 4267592..4267849 + 258 WP_231026176.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LQ955_RS19795 (LQ955_19795) 4267846..4268283 + 438 WP_231026177.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ955_RS19800 (LQ955_19800) 4268293..4269015 - 723 WP_231026178.1 alpha/beta hydrolase -
LQ955_RS19805 (LQ955_19805) 4269120..4269533 + 414 WP_231026179.1 MarR family transcriptional regulator -
LQ955_RS19810 (LQ955_19810) 4270408..4271352 - 945 WP_231026180.1 DUF2090 domain-containing protein -
LQ955_RS19815 (LQ955_19815) 4271451..4271789 - 339 WP_231026181.1 hypothetical protein -
LQ955_RS19820 (LQ955_19820) 4271800..4272465 + 666 WP_231026182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(15-138)

Antitoxin

Antitoxin VapB-like

(1-82)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15232.26 Da        Isoelectric Point: 4.1862

>T226541 WP_231026177.1 NZ_CP087997:4267846-4268283 [Subtercola sp. AK-R2A1-2]
VILDTSAVILDTSAVVLDTSAVIALVNREPEWRAVFDRIDGAGEVRMSSVSLLELSIVLGSPRFGMSRSEVAALLESMGV
ATVAFTPDHAVLAAEAYARYGKGNHPARLDFGDCAAYATAVLDGGSLLFVGEDFVQTDVRSALGE

Download         Length: 438 bp

>T226541 NZ_CP122507:c4282110-4281937 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9257.59 Da        Isoelectric Point: 5.1053

>AT226541 WP_231026176.1 NZ_CP087997:4267592-4267849 [Subtercola sp. AK-R2A1-2]
MGLNLKDDETVALVSEVARRLGLTKTGAVRELARAKLADLDAQSALKSSTLLRYLESEVWPHTVGAPVSKTERESIVGYD
EMLSV

Download         Length: 258 bp

>AT226541 NZ_CP122507:c4282434-4282138 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References