Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2333775..2334397 Replicon chromosome
Accession NZ_CP087997
Organism Subtercola sp. AK-R2A1-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LQ955_RS10915 Protein ID WP_231028113.1
Coordinates 2333775..2334167 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LQ955_RS10920 Protein ID WP_231024574.1
Coordinates 2334167..2334397 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LQ955_RS10890 (LQ955_10890) 2329373..2330206 + 834 WP_231024569.1 mycofactocin-coupled SDR family oxidoreductase -
LQ955_RS10895 (LQ955_10895) 2330262..2331095 + 834 WP_231024570.1 mycofactocin-coupled SDR family oxidoreductase -
LQ955_RS10900 (LQ955_10900) 2331098..2331931 + 834 WP_231024571.1 mycofactocin-coupled SDR family oxidoreductase -
LQ955_RS10905 (LQ955_10905) 2332074..2332400 - 327 WP_231024572.1 toxin-antitoxin system HicB family antitoxin -
LQ955_RS10910 (LQ955_10910) 2332740..2333633 - 894 WP_231024573.1 DUF4349 domain-containing protein -
LQ955_RS10915 (LQ955_10915) 2333775..2334167 - 393 WP_231028113.1 type II toxin-antitoxin system VapC family toxin Toxin
LQ955_RS10920 (LQ955_10920) 2334167..2334397 - 231 WP_231024574.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LQ955_RS10925 (LQ955_10925) 2334424..2335173 - 750 WP_231024575.1 DUF4253 domain-containing protein -
LQ955_RS10930 (LQ955_10930) 2335424..2336881 + 1458 WP_231024576.1 DUF3375 domain-containing protein -
LQ955_RS10935 (LQ955_10935) 2336881..2337537 + 657 WP_231024577.1 DUF4194 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-42)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14274.48 Da        Isoelectric Point: 5.5511

>T226536 WP_231028113.1 NZ_CP087997:c2334167-2333775 [Subtercola sp. AK-R2A1-2]
MRLLLDTHTSYWAVSEPSRIPAAAVDLIEQPQNELLVSAITPWELGIKFRKGKFPEAGPFLAAFPRHMGTLGAIELPISS
EHALIAAQIDWTHRDPFDRMLAAQAILENAVLITADTVFASLGGLRVSWS

Download         Length: 393 bp

>T226536 NZ_CP122507:3534993-3535211 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8560.65 Da        Isoelectric Point: 4.2958

>AT226536 WP_231024574.1 NZ_CP087997:c2334397-2334167 [Subtercola sp. AK-R2A1-2]
MTETVNVQDAKTRLSELLARVERGEEFILARNGRPIATLRALDPLPRRQLGFAPGPALPESFWDPLTDDELDEWGT

Download         Length: 231 bp

>AT226536 NZ_CP122507:3534593-3534967 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References