Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 2086866..2087413 Replicon chromosome
Accession NZ_CP087994
Organism Acetobacterium wieringae strain Y

Toxin (Protein)


Gene name relE Uniprot ID A0A1F2PDS3
Locus tag LNN31_RS09715 Protein ID WP_070372270.1
Coordinates 2087138..2087413 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1F2PDT0
Locus tag LNN31_RS09710 Protein ID WP_070372269.1
Coordinates 2086866..2087141 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN31_RS09690 (LNN31_09665) 2082531..2083481 - 951 WP_228879645.1 methyl-accepting chemotaxis protein -
LNN31_RS09695 (LNN31_09670) 2083498..2084598 - 1101 WP_228879643.1 FIST N-terminal domain-containing protein -
LNN31_RS09700 (LNN31_09675) 2084944..2085822 - 879 WP_228879640.1 AraC family transcriptional regulator -
LNN31_RS09705 (LNN31_09680) 2085889..2086323 - 435 WP_228879637.1 BRO family protein -
LNN31_RS09710 (LNN31_09685) 2086866..2087141 + 276 WP_070372269.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LNN31_RS09715 (LNN31_09690) 2087138..2087413 + 276 WP_070372270.1 type II toxin-antitoxin system YafQ family toxin Toxin
LNN31_RS09720 (LNN31_09695) 2087699..2088052 + 354 WP_148637101.1 HNH endonuclease signature motif containing protein -
LNN31_RS09725 (LNN31_09700) 2088057..2088371 - 315 WP_070372272.1 type II toxin-antitoxin system RelE/ParE family toxin -
LNN31_RS09730 (LNN31_09705) 2088358..2088630 - 273 WP_070372273.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LNN31_RS09735 (LNN31_09710) 2088693..2089216 + 524 Protein_1885 ParB N-terminal domain-containing protein -
LNN31_RS09740 (LNN31_09715) 2089557..2090012 + 456 WP_070372276.1 transposase -
LNN31_RS09745 (LNN31_09720) 2089975..2091548 + 1574 Protein_1887 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(32) - 2056056..2160140 104084


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-73)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10856.51 Da        Isoelectric Point: 6.2245

>T226530 WP_070372270.1 NZ_CP087994:2087138-2087413 [Acetobacterium wieringae]
MKYEVKFTNQFKKDLKLAKKQGRDIDRLYAVIEKLADDEPLEQKYRDHDLSGNYKGCRECHVEPDWLLVYEVMDDVLVLM
LYRIGSHSTLF

Download         Length: 276 bp

>T226530 NZ_CP122507:2020185-2020288 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10059.47 Da        Isoelectric Point: 4.8279

>AT226530 WP_070372269.1 NZ_CP087994:2086866-2087141 [Acetobacterium wieringae]
MATSTNLNIRTDKDIKEAAEKIFGELGLNMTTAINIFLRQAIRENGIPFEMKLSVPNQETVAAITEGRKLAKDSSVKGYS
NMDDLRAALEE

Download         Length: 276 bp

>AT226530 NZ_CP122507:c2020326-2020055 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2PDS3

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2PDT0

References